Even the detrimental role of high fat intake and the protective effect of fibre have to be qualified. In order to improve knowledge on the etiopathogenesis of colorectal cancer, more attention should be directed to the modifiers of the action of carcinogenic or anticarcinogenic substances. Sex, ...
A positive dose‐response effect was found in two of three cohort studies and in all four case‐control studies with community controls in which this effect was examined. In both case‐control and cohort studies, the association was found for females and males and for colon and rectal cancer....
Regrowth Predicts Metastasis in Rectal Cancer Watch and Wait Brain Metastasis Patterns Affect Breast Cancer Survival The Interpretation and Management of Hypercalcemia in Primary Care The Interpretation and Management of Hypocalcemia JAK Inhibitors: Too Many Choices or Not Enough? Tools Drug Interactio...
A 41-year-old Chinese male patient presented with a 1-year history of dry stool, which progressed to rectal bleeding for 1 month. He had undergone perianal abscess surgery in 2009. Colonoscopy revealed circumferential mucosal erosion and granular or nodular protrusions covered with fragile, white ...
Abstract 2305: Ultra-sensitive detection of circulating tumor DNA by whole-genome sequencing of blood samples from locally advanced rectal cancer patients ... WGS data identified multiple patients with colibactin associated mutational signatures, which provides additional insights into their cancer etiology...
Fecal incontinence is a challenging condition of diverse etiology and devastating psychosocial impact. Multiple mechanisms may be involved in its pathophysiology, such as altered stool consistency and delivery of contents to the rectum, abnormal rectal capacity or compliance, decreased anorectal sensation, ...
Assessing each of these risks is the first step in predicting the likelihood of a positive margin during surgery. Clinical stage and tumor volume Digital rectal examination cannot accurately predict the pathological stage of prostate cancer.24, 36, 44, 51 Nonetheless, clinical stage correlates with ...
The patient’s father and brother had lung and gastric cancers, respectively; however, the patient had no family history of colorectal polyposis or cancer. Colonoscopy revealed > 100 polyps, with a normal mucosal background confined from the cecum to the splenic flexure of the transverse colon...
Rectal distension stimulates the sphincter relaxation reflex (rectoanal inhibitory reflex) which depends on the ENS. Formation of the ENS requires extensive cell migration, controlled cell proliferation, regulated differentiation, directed neurite growth, and interconnected neuron networks [1]. The ...
Physical activity and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Higher levels of physical activity have been consistently associated with a decreased risk of colon cancer, but not rectal cancer, in Western populations. ....