20938). Moreover, caffeine-mediated neurotoxic effects were noted via neural repair suppression and neuroinflammation induction following spinal cord injury (Yang and Jou, 2016, pii: S0006-8993(15)00992-0.). Combined use of 3,4-methylenedioxymethamphetamine (MDMA) and caffeine in adolescent mice ...
NeuroinflammationDoxycycline (DOXY) is a second-generation tetracycline with anti-inflammatory and neuroprotective effects. A proinflammatory profile seems to predict the severity of depressive symptoms. In the present study, we aimed at determining whether the anti-inflammatory action of subantimicrobial-...
NeuroinflammationHighlights ? 7-day treatment with escitalopram (ESC) is effective in 50% of rats in the CED model. ? ESC-responders showed decreased CHR/CRHRs mRNAs and altered GR in hypothalamus. ? Response to ESC correlated with a decrease in circulating corticosterone. ? IL-6 and ADAM17 ...
Neuroinflammation, oxidative and nitrosative stress, and monoaminergic and neuroplasticity imbalance seem to play an essential role Drugs We used Lipopolysaccharide (LPS) from Escherichia coli, strain 055:B5 (Sigma–Aldrich Corp., St Louis, USA), doxycycline (DOXY; Sigma–Aldrich Corp., St Louis,...
Neuroinflammation in patients with major depressive disorder (MDD), in turn, may reduce likelihood of improvement with serotonergic antidepressants. Methods: Levels of S100B were measured in plasma samples obtained prior to initiation of treatment with bupropion-plus-escitalopram, escitalopram-plus-placebo...