大肠杆菌(Escherichia coli),在1885年发现的,在相当长的一段时间内,一直被当作正常肠道菌群的组成部分,认为是非致病菌。直到20世纪中叶,才认识到一些特殊血清型的大肠杆菌对人和动物有病原性,尤其对婴儿和幼畜(禽),常引起严重腹泻和败血症。大肠杆菌又是如何产生的呢?又当如何消灭呢?L就爱涨知识的秒拍视频 ...
1-Decanol has great value in the pharmaceutical and fragrance industries and plays an important role in the chemical industry. In this study, we engineered Escherichia coli to selectively synthesize 1-decanol by using enzymes of the core reverse β-oxidation (rBOX) pathway and termination module ...
大肠杆菌(Escherichia coli,E. coli)在生物制药工业中生产重组蛋白方面发挥了重要作用,它是第一个用于生产生物药物的表达载体,其发展促使了1982年首个生物技术产品Humulin®(用于治疗糖尿病的人胰岛素)的诞生。E.coli具有生长快速、基因操作方便、重组蛋白合成速度快等优点,也存在一些固有障碍,如密码子使用偏好、缺乏翻...
Cytotoxic necrotizing factor 1 (CNF1), a 110-kDa protein toxin from pathogenic Escherichia coli induces actin reorganization into stress fibers and retraction fibers in human epithelial cultured cells allowing them to spread. CNF1 is acting in the cytosol since microinjection of the toxin into HEp...
However, Escherichia coli Nissle 1917 (EcN) is another promising candidate with probiotic properties. EcN offers increased applicability for cancer treatment with the development of new molecular biology and complete genome sequencing techniques. In this review, we discuss the genetics and physical ...
Escherichia coli is the leading cause of neonatal Gram-negative bacterial meningitis, but the pathogenesis of E. coli meningitis remains elusive. E. coli penetration of the blood–brain barrier (BBB) is the critical step for development of meningitis. He
Samples collected from feed, hogs, hog houses, waste lagoon, soil, surface water and well water were screened for the presence of (a) resistant Escherichia coli and...年份: 2004 收藏 引用 批量引用 报错 分享 全部来源 求助全文 ResearchGate 相似文献...
Young chicks were inoculated with six different strains of attaching and effacing Escherichia coli isolated from the feces of calves, pigs, chicks, and humans. Colibacilli of some serotypes had colonized the cecum of chicks by 7 days after inoculation. The characteristic lesions associated with bact...
PURPOSE:To obtain novel Escherichia coli capable of producing a heat-resistant leucine dehydrogenase having heat stability, not losing activity for a long time at room temperature. CONSTITUTION:Novel Escherichia coli C600-pICR1 strain (FERM P 6937) transformed with a plasmid having a gene of leucine...
We did this study to investigate the prevalence of the mcr-1 gene in clinical isolates from patients with bloodstream infections in China. Clinical isolates of Escherichia coli and Klebsiella pneumoniae were collected from patients with bloodstream infections at 28 hospitals in China, then screened ...