Special conditions within the tumor microenvironment and highenergy demands lead to alterations in the energy metabolism of T cells. In-depth research on the reprogramming of energy metabolism in T cells can reveal the mechanisms underlying tumor immune tolerance and provide ...
lism in tumor cells Energy metabolism in tumor cellsEnergy metabolism in tumor cellsdoi:10.1111/j.1742-4658.2007.05686.xcasiopeinaschemotherapyglycolysismetabolic control analysismitochondrial metabolismPETrhodaminesIn early studies on energy metabolism of tumor cells, it was proposed that the enhanced ...
Tumor cells require significant energy and materials for rapid growth, and their metabolism is regulated through aerobic glycolysis and mitochondrial oxidative phosphorylation. This adaptation helps cells thrive in the low-oxygen tumor microenvironment. It also provides the energy and materials needed for b...
The last decade has witnessed the accumulation of a formidable body of evidence that matter/energy metabolism in tumor cells is quite distinct from that of most normal cells. At the same time, diverse data indicate that the redox metabolism (including generation of reactive oxygen species; ROS) ...
Methods Cell survival and bioenergetics metabolism were assessed in lung cancer cell lines. Our in-house small-molecule compounds were screened to identify those that kill cancer cells under low-glucose conditions. Cytotoxicity against non-cancerous cells was also assessed. Tumor growth was evaluated ...
status to respond to the higher metabolic costs for ECM remodeling while moving forward compared to the cells behind the tumor center [6,7]. However, whether similar leader cells with strong metabolism exist in the tumor margin of OSCC and how these cells obtain extra energy are still unknown...
CANCER cellsTUMOR growthLACTATE dehydrogenaseMITOCHONDRIARESEARCHThe article relates the study that examined the growth of tumor cells and examined the function of the mitochondria when lactate production is compromised. One of the enzymes involved in lactate production is lactate dehydrogenase A (LDHA). ...
Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 1981; 256: 8699–8704. CAS PubMed Google Scholar Rempel A, Mathupala SP, Griffin CA, Hawkins AL, Pedersen PL . Glucose catabolism in cancer cells: amplification ...
In particular, metabolic and energetic changes have been observed in cancer cells even before the discovery of oncogenes and tumor suppressors, but have been neglected for a long time. Instead, during the past 20 years a renaissance of the study of tumor metabolism has led to a revised and ...
Energy Metabolism in Cells 来自 Springer 喜欢 0 阅读量: 46 作者: ArthurT.Winfree 摘要: Glycolysis: Lacking illuminated chloroplasts or lacking oxygen, cells metabolize sugars by fermentation to make a little ATP from ADP. Historically, this was probably the first way to make the high-energy ...