St. John's wort (SJW), a widely used herbal product, has been implicated in drug interactions resulting from the induced expression of the cytochrome P450 CYP3A4 isoform. In this study, we determined the effect of SJW on the metabolism of irinotecan, a pro-drug of SN-38 and a known ...
Common side effects of St. John's wort may include: sleep problems (insomnia), strange dreams; feeling anxious, irritable, or restless; dry mouth, upset stomach, diarrhea; skin rash, tingly feeling; headache, dizziness; or tired feeling. ...
Tacrolimus is an immunosuppressant approved for the prevention of rejection following transplantation and is a substrate for CYP3A and P-glycoprotein. A pharmacokinetic interaction between St. John's wort (antidepressant herbal product and inducer of CYP3A and P-glycoprotein) and tacrolimus was evaluated...
St. John's wort has been tried to help quit smoking, forfibromyalgia, chronic fatigue syndrome (CFS), burning feelings in the mouth,migraineand other types of headaches, muscle pain, nerve pain and nerve damage throughout the body, pain that travels down the sciatic nerve in the leg, and...
St John's Wort, a widely used herbal product, is an inducer of CYP3A4 and it decreases blood concentrations of CYP3A4 substrates. The effects of St John's Wort on the pharmacokinetics of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors simvastatin (an inactive lactone pro-drug) ...
This research was conducted to investigate effects of morphogenetic and diurnal variability on the hypericin content of St. Johnrsquo;s Wort (Hypericum perforatum L.) populations originating from Turkey for maximum utilization of the active substance in plants. During 2002 and 2003, field trials were...
Plans to develop a form of hypericum [St John's wort] with fewer adverse effects. React. Wkly. 819, 2 (2000). https://doi.org/10.2165/00128415-200008190-00003 Download citation Published09 February 2013 Issue DateSeptember 2000 DOIhttps://doi.org/10.2165/00128415-200008190-00003 Keywords Publ...
However, these changes might be ascribed to the combined effect of terpenes, tannins, quercetin and flavonoids present in SJW. Keywords: St. John's Wort Supplement; cytology; somatic cells; germ cells; nucleic acids; malondialdehyde; nonprotein sulfhydryl groups. Introduction Commercially available St...
The present study provides conclusive evidence that St John's Wort is an effective antidepressant with relatively benign side-effects, and may be a better choice for the treatment of mild moderate depression than synthetic antidepressants.doi:10.1185/135525702125000435David Wheatley...
Preliminary results indicated that treatment with St. John's wort alters the plasma pharmacokinetics of doxorubicin. Our studies suggest that even relatively high doses of vitamin E do not adversely affect the toxicity of doxorubicin. On the other hand, St. Johns wort may decrease peak levels of...