A. et al. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154, 442–451 (2013). This study demonstrates transcription repression by KREB fused to dCas9. Article CAS PubMed PubMed Central Google Scholar Gilbert, L. A. et al. Genome-scale CRISPR-mediated ...
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They were first established by fusing the transcription activator Vps64 or the Krüppel-associated box (KRAB) repressor to dCas9 (Gilbert et al., 2013). Endeavors have been made to improve the efficacy of these effectors, e.g., CRISPRa effectors were further improved by fusing a repeating ...
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2024, Nature Reviews Neuroscience Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput 2024, Nature Methods Methods for Functional Characterization of Genetic Polymorphisms of Non-Coding Regulatory Regions of the Human Genome 2024, Biochemistr...
Kinetic Constructs LLC combines a bioscience research background with expertise in science communication. Judith A Gilbert, president of and writer for Kinetic Constructs, has an MS in biochemistry, a BA in microbiology, and more than thirty years of experience in research laboratories in the life ...
Targeted genome-modification tools and their advanced applications in crop breeding 2024, Nature Reviews Genetics Exonuclease-enhanced prime editors 2024, Nature Methods Prime editing: Mechanism insight and recent applications in plants 2024, Plant Biotechnology Journal View all citing articles on Scopus ...
Nature Reviews Drug Discovery volume 19, pages 839–859 (2020)Cite this article 39k Accesses 503 Altmetric Metrics details Abstract Base editing — the introduction of single-nucleotide variants (SNVs) into DNA or RNA in living cells — is one of the most recent advances in the field of ...
crRNAs guide the effector complex to the target site and cleave the DNA producing DSBs in the re-invading viruses. There are excellent reviews on the biology of CRISPR [70,74,76]. This review will focus on the effectors including endonucleases because these nucleases are used for genome editi...