Objectives To determine whether there is a relationship between early life adversity (ELA) and biological parameters known to predict health risks and to examine the extent to which circumstances in midlife mediate this relationship. 机译:目的确定早期逆境(ELA)与已知可预测健康风险的生物学参数之间是否...
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological mechanisms by which ELA increases the risk for future psychopathology are still poorly understood. Brain development is particularly malleable during prenatal and early postnatal life, when complex neural circu...
To assess eating behaviors, early life adversity, and level of resilience, each participant was asked to fill out the Yale Food Addiction Scale (YFAS, food addiction), Early Traumatic Inventory (ETI, ELA) and Brief Resilience Scale (BRS, resilience) questionnaires. ...
Early life adversity (ELA) affects brain structure and function and results in blunted stress axis reactivity. In this review, we focus on the underlying neurobiological mechanisms associated with a blunted response to stress, ELA, and risk for addictive disorders. ELA and blunted reactivity are ...
Early-life stress (ELS) arising from physical and emotional abuse disrupts normal brain development and impairs hypothalamic–pituitary–adrenal axis function, increasing the risk of psychopathological disorders and compulsive behaviors in adulthood. How
Early-life adversity (ELA) includes experiences of abuse, neglect, caregiver death, exposure to stressors associated with low socioeconomic status, and other traumatic events that threaten a child’s safety. Epidemiological studies provide robust evidence of associations between ELA and a variety of ...
Two-thirds of Scottish children experience early life adversity - such as domestic violence or parental drug abuse - according to a new study. Researchers at the University of Edinburgh found that boys are at greatest risk, along with those from low-income households and those with younger ...
Suicide is a complex phenomenon, and the neurobiological changes occurring that lead to suicide remain unknown. The early-life period is a critical period of brain development, and it is now well established that early-life adversity, such as childhood abuse, is highly associated with suicide and...
These discoveries suggest that early-life adversity, especially in the perinatal period, influences the maturation of brain circuits involved in cognition. Importantly, new findings suggest that fragmented and unpredictable environmental and parental signals comprise a novel potent type of adversity, which ...
Early life adversity induces social subordination and increased explorative behavior To address the consequences of ELS, we subjected C57BL/6 pups to unpredictable maternal separation and maternal stress between PND 2 and PND 14 (Fig. 1a). ELS mice initially displayed lower body weight during the ...