Objectives To determine whether there is a relationship between early life adversity (ELA) and biological parameters known to predict health risks and to examine the extent to which circumstances in midlife mediate this relationship. 机译:目的确定早期逆境(ELA)与已知可预测健康风险的生物学参数之间是否...
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological mechanisms by which ELA increases the risk for future psychopathology are still poorly understood. Brain development is particularly malleable during prenatal and early postnatal life, when complex neural circu...
and early life adversity (ELA) also increases alterations in these same reward regions. However, the neural mechanisms underlying the effect of early life adversity on food addiction are unknown. Therefore, the aim of this study was to examine the interactions between ELA, food addiction...
Early-life stress (ELS) arising from physical and emotional abuse disrupts normal brain development and impairs hypothalamic–pituitary–adrenal axis function, increasing the risk of psychopathological disorders and compulsive behaviors in adulthood. How
Early-life adversity (ELA) includes experiences of abuse, neglect, caregiver death, exposure to stressors associated with low socioeconomic status, and other traumatic events that threaten a child’s safety. Epidemiological studies provide robust evidence of associations between ELA and a variety of ...
Childhood adversity and maltreatment, encompassing early life stressful events ranging from parental illness or divorce to more severe cases of physical and sexual abuse, represents a significant risk factor for adult mental health outcomes include alcoh
Two-thirds of Scottish children experience early life adversity - such as domestic violence or parental drug abuse - according to a new study. Researchers at the University of Edinburgh found that boys are at greatest risk, along with those from low-income households and those with younger ...
Early-life adversity—such as poverty, illness or family conflict—has long been linked to mental health difficulties and poorer cognitive functioning as children grow up. But how these factors interact and evolve over time has so far been unknown.
There are many ‘faces’ of early life adversity (ELA), such as childhood trauma, institutionalisation, abuse or exposure to environmental toxins. These have been implicated in the onset and severity of a wide range of chronic non-communicable diseases later in life. The later-life disease risk...
Early life adversity induces social subordination and increased explorative behavior To address the consequences of ELS, we subjected C57BL/6 pups to unpredictable maternal separation and maternal stress between PND 2 and PND 14 (Fig. 1a). ELS mice initially displayed lower body weight during the ...