Brief cognitive screening tests performed by primary care physicians provide effective information for Alzheimer's patients and families regarding recent changes in daily living, behavior, intellectual functioning, and mood. In this review, we consider information in the literatureconcerning the practicality...
The Social Security Administration has added early-onset/ younger onset Alzheimer’s to the list of conditions under its Compassionate Allowance Initiative. This expedites access to Social Security Disability Insurance and Supplemental Social Income for individuals with the disease. (5) Sources: (1) A...
safety and efficacy of lecanemab; potential regulatory discussions, submissions and approvals and the timing thereof; the treatment of Alzheimer's disease; the anticipated benefits and potential of Biogen's collaboration arrangements with Eisai; the potential...
R., Yanai, K. and Arai, H. (2007) 2-(2-[2-Dimethylaminothiazol-5-yl] ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole: A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer’s disease patients. Journal of Nuclear Medicine, 48, 553-561. doi:10.2967/jnumed.106.037556...
Amyloid plaques associated with Alzheimer's disease (AD) induce inflammatory responses associated with activated microglia and reactive astrocytes, which exacerbate neurodegeneration through release of inflammatory cytokines, reactive oxygen species, and other factors. Inflammation contributes to neurodegeneration ...
Early detection of Alzheimer’s disease with a total score of the German CERAD. J Int Neuropsychol Soc. 2010;16(5):910–20. Article PubMed Google Scholar de Boer C, Echlin HV, Rogojin A, Baltaretu BR, Sergio LE. Thinking-while-moving exercises may improve cognition in elderly with ...
Current, generally held ideas about the pathology underlying Alzheimer’s disease (see main text for details). The transition from normal cognition to dementia, over decades, is promoted by the risk factors shown above the large red arrow. Aβ is produced from amyloid precursor protein (APP) by...
Alzheimer's disease (AD), the most common form of dementia, is characterized by progressive neurodegeneration (Andrieu et al., 2015). Research on AD has predominantly focused on cognitive decline and memory loss (Jack et al., 2011; Perrin et al., 2009). However, visual dysfunction is common...
The rapid development of metabolomics is inextricably linked to advancements in its technology. Liquid chromatography (LC) and gas chromatography (GC) are the most prevalent methods for metabolite separation, while metabolite detection primarily relies on nuclear magnetic resonance (NMR) and mass spectrome...
Protein digestion for serum samples were performed using a modified Filter-Aided Sample Preparation (FASP) method43. To prepare the LAPs and HAPs peptides for MS detection, 500 μg protein samples were diluted by 400 μL lysis buffer (6 M urea and 1× protease inhibitor cocktail). Th...