Dystrophy refers to abnormal development or growth, often due to genetic mutations. Atrophy describes a decrease in size or wasting away of a body part, typically due to underuse or disease.
Medtalk Partial atrophy of tissue or an organ attributed to ↓ nutrition. See Becker's muscular dystrophy, Benign pseudohypertrophic muscular dystrophy, Hyperplastic dystrophy, Lattice dystrophy, Map-dot dystrophy, Myotonic dystrophy, Neuroaxonal dystrophy, Reflex sympathetic dystrophy, Spider dystrophy, Th...
This autosomal recessive inherited trait occurs in Pietrain pigs that are susceptible to stress.962,963Muscular weakness is noted at 3 weeks and progresses to recumbency by 12 weeks. These pigs have a crouched posture and a creeping-type gait using flexed limbs. Atrophy of type I myo...
(now Novartis Gene Therapies), Biogen Inc, Pfizer, Vertex, Roche, and Genentech; receiving research support from the National Institute of Neurological Disorders and Stroke, the Slaney Family Fund, the Spinal Muscular Atrophy Foundation, Cure SMA, and Working on Walking Fund; receiving grants from...
aggregates (Davies et al., 2005). More recently, a group demonstrated that a two-AAV “silence” and “replace” vector-based gene therapy treatment in a mouse model of OPMD reverted already established insoluble aggregates and partially rescued the muscle from atrophy (Malerba et al., 2019)...
Most patients (41.7%) showed chorioretinal atrophy at baseline. All OCT parameters showed significant age-related loss (<0.05), with EZ measures and choroidal thickness displaying the most rapid degeneration (2.3–3.3% per year vs 0.6–1.5% per year). Median BCVA was 0.2 LogMAR (IQR: 0–...
et al. Parental attitudes toward newborn screening for Duchenne/Becker muscular dystrophy and spinal muscular atrophy. Muscle Nerve 49, 822–828 (2014). Article CAS PubMed Google Scholar Bianchi, D. W. & Chiu, R. W. K. Sequencing of circulating cell-free DNA during pregnancy. N. Engl....
Regional brain atrophy and functional disconnection across Alzheimer’s disease evolution. J Neurol Neurosurg Psychiatry. 2011;82(1):58-66.PubMedGoogle ScholarCrossref 18. Koch W, Teipel S, Mueller S, et al. Diagnostic power of default mode network resting state fMRI in the detection of ...
Anthropometric measurement standardization for a multicenter nutrition survey in children with spinal muscular atrophy. Eur J Clin Nutr. 2019;73(12):1646–8. Article Google Scholar Download references Acknowledgements We are grateful to the DMD patients and their families, the North Star clinical ...
Physiologic muscle atrophy occurs from prolonged periods of time when muscles are not used at all or not used enough. In other words, "use it or lose it" as the adage goes. While significant muscle atrophy can take time, signs of atrophy on a molecular level can begin as early as after...