Dystrophin expression in the human retina is required for normal function as defined by electroretinography. Nat Genet. 1993;4:82- 86.Dystrophin expression in the human retina is required for normal function as defined by electroretinography. Nature Genet - D-AM, DE - 1993...
This network of interactions contributes to the plasma membrane stability in normal conditions, on the other hand, the connection between the cytosol and the extracellular matrix needs to be interrupted when tissue remodeling takes place. In such circumstances, an overexpression of some matrix–metallopr...
7.The patients from 5 DMD and 2 BMD were detected by immunofluorescence technique for analyzing dystrophin located in muscle cell membrane, compared with 2 normal males. 并采用免疫荧光抗体染色技术对5例dmd,2例BMD肌细胞膜上抗肌营养不良蛋白的表达观察分析,以2例正常人的肌组织作为对照。
Dystrophin expression in the human retina is required for normal function as defined by electroretinography We have studied retinal function by electroretinography in five Becker and six Duchenne muscular dystrophy patients. All had abnormal electroretinograms wi... DAM Pillers,DE Bulman,RG Weleber...
The normal intellectual capabilities of the patient argue against an indispensable role of the brain-specific first exon in mental functioning. The possibility exists that a NH 2 -terminally truncated dystrophin has taken over the function of the normal dystrophins in brain and/or muscle. 展开 ...
Dystrophin is localized, in normal muscle fibers, on the cytoplasmic surface of the sarcolemma. The function of this protein is not known but, according to
Restora- tion of normal muscle morphology and function has been previously observed in transgenic rndx mice expressing dys- trophin (4-6). This study suggests that after intramuscular injection of plasmid DNA, mdx myofibers expressing either full-length or Becker-like dystrophin are corrected for ...
It is presumed that normal skeletal muscle function in these patients increases the cardiac preload, likely accelerating the development of cardiomyopathy. Some families and individuals become socially withdrawn, which may further affect their overall psychosocial health. Family, financial, school, community...
The treated mice show persistent production of dystrophin at normal levels in large numbers of muscle fibers and show functional improvement of the treated muscle. Repeated administration enhances dystrophin expression without eliciting immune responses. Our data establishes the realistic practicality of an ...
5.3.2.3.13 Function of major histocompatibility complex in Duchenne muscular dystrophy Muscle cells do not express MHC class II antigens under normal physiological circumstances. They may express in a few inflammatory myopathies and also serve as significant markers of inflammation. Additionally, the ...