GenAI represents a dual-edged sword for cybersecurity. While it necessitates a reevaluation of cybersecurity strategies to protect large language models, it also promises enhanced threat detection, predictive capabilities and operational efficiency. The key lies in utilizing its benefits while proactively...
Muolo, Paul
the definite role of MMPs in neurological recovery post-TBI remains elusive, since it depends on where and when it is activated [138]. After severe TBI, astrocytes induce the expression of MMP-3 in a higher and more persistent pattern, resulting in maladaptive synaptogenesis and poor ...
explaining the aggressive phenotype and poor prognosis of AML [92]. In AML cells, FLT3-ITD expression leads to increased basal autophagy, which is required for
The high expression of G-CSF in tumor cells or tissues has been associated with more robust metastatic potential in preclinical tumor models3,13, and poor prognoses in patients with solid tumors42,43. To further evaluate whether the presence or absence of NK cells is a key factor in ...
HEK-Dual™ hTLR3 cellsfeature the stable expression of theTLR3gene as well as two inducible reporter genes for SEAP (secreted embryonic alkaline phosphatase) and Lucia luciferase. As a result, these cells allow the simultaneous study of the NF-κB pathway, by monitoring the activity of SEAP...
Western blot analysis showed reduced ASC expression in most metastatic melanoma cell lines (Figure 1b). To investigate expression-dependent and/or stage-dependent roles of ASC in human melanoma, we used two primary melanoma cells, WM35 and WM115, expressing relatively higher (WM35) and lower (...
Introduction NF-κB is ubiquitously expressed in peripheral and brain cells and regulates the expression of a wide variety of genes involved in cell survival, growth, stress responses, and im- mune and inflammatory processes[1–3]. This factor was first described by Sen and Baltimore in 1986 ...
(Fig. S1a, b). The peak positions indicated hDUOX1 migrated as a monomer, while hDUOX1–hDUOXA1 complex migrated as a heterotetramer (Fig. S1b). Moreover, we found the co-expression of DUOX1 and DUOXA1 resulted in cell membranes that showed robust calcium-activated, NADPH-dependent ...
The DUSP28 expression profile was obtained using the public microarray database GEO of human pancreatic cancer samples. As shown in Fig. 1, pancreatic cancers expressed significantly more DUSP28 mRNA than the normal pancreatic samples. Specifically, adenocarcinoma of the pancreas (n = 55, GSM...