Drug Metabolism: Other Phase I EnzymesGianluca CatucciGianfranco GilardiSheila J. SadeghiComprehensive Pharmacology
culture suggest that this model system is not reflective of in vivo profiles and, therefore, may be limited in its application for drug metabolism studies... EL Lecluyse - 《European Journal of Pharmaceutical Sciences》 被引量: 760发表: 2001年 Assessment of pharmacological treatment of myocardial...
2. Factors such as age, gender, race, environment, and drug treatment may have considerable influence on the activity of these enzymes. 3. There are now well-established in vitro techniques for assessing the role of specific cytochrome P450 enzymes in the metabolism of drugs, as well as the...
网络药物代谢酶 网络释义 1. 药物代谢酶 2.药物代谢酶药物在体内的转化是在酶的催化下进行,这些催化药物转化的酶,统称为药物代谢酶(drug metabolism enzyme… book.jd.com|基于13个网页
"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation." Pharmacol Ther 138(1): ... UM Zanger,M Schwab - 《Pharmacology & Therapeutics the Journal of the International Encyclopedia of Pharmacology & Therapeutics》 被引量: 0发...
Molecular Biology Reports (2020) 47:393–400 https://doi.org/10.1007/s11033-019-05143-5 ORIGINAL ARTICLE Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population Yaya Kassogue1 · Brehima Diakite1 · Oumar Kassogue1...
Drug induced bile duct injury is a frequently observed clinical problem leading to a wide range of pathological features. During the past decades, several agents have been identified with various postulated mechanisms of bile duct damage, however, mostly
ICH指南中概述的遗传毒性测试仅用于鉴别引起直接遗传损伤的药物。这一点非常重要,因为现在人们已经知道,新药产品还可以通过许多非遗传毒性机制来增加致癌风险,包括激素调节、刺激和炎症、免疫抑制、细胞信号通路抑制,以及其他一系列有利于肿瘤形成的表观遗传效应。
other specialized TMEs will be beneficial in the development of potential cancer therapies.249With respect to the different hallmarks of the TME, in the current section we will elaborate on the tumor immune microenvironment (TIME), metabolism microenvironment, hypoxic microenvironment, acidic niche, ...
Differentiation of Monkey Embryonic Stem Cells into Hepatocytes and mRNA Expression of Cytochrome P450 Enzymes Responsible for Drug Metabolism : Comparison... and Ohmori, S.: Differentiation of monkey embryonic stem cells into hepatocytes and mRNA expression of cytochrome P450 enzymes responsible for drug...