drug interaction ‐ between one medicament and another in humanspharmacokinetic drug–drug interaction ‐ determination of free form of medicament in blood, and/or target tissuepharmacodynamic drug–drug interaction ‐ biological and physiological effects of drugs, and their mechanisms...
Huppertz A, Breuer J, Fels LM, Schultze-Mosgau M, Sutter G, Klein S et al (2011) Evaluation of possible drug-drug interaction between gadoxetic acid and erythromycin as an inhibitor of organic anion transporting peptides (OATP). J Magn Reson Imaging 33:409–416...
Drug: polymer interaction in the all-trans retinoic acid release from chitosan microparticles. J Therm Anal Cal. 2007;87:899–903. View ArticleLira A, Nanclares D, Neto A, Marchetti J. Drug-polymer inter- action in the all-trans retinoic acid release from chitosan micro- particles. J Therm...
Paclitaxel is mainly eliminated by CYP2C8 in the liver. CYP2C8 is strongly inhibited by the clopidogrel metabolite acyl--D-glucuronide. To determine if this interaction has clinical relevance, we identified 48 patients treated with clopidogrel and paclitaxel using databases and a prescription ...
drug–drug interactiontherapeutic proteincytokinemonoclonal antibodycytochrome P450Kraynov, EugeniaPharmacokinetics, Dynamics & Metabolism Pfizer Inc. San Diego CAMartin, Steven WGlobal Pharmacometrics, GIPB Clinical Pharmacology Pfizer Inc. Cambridge MAJohn Wiley & Sons, Inc....
Summary This chapter contains sections titled: Introduction Mechanisms of Adverse Drug–Drug Interactions Drug Metabolism CYP Isoforms Human In Vitro Experimental Systems for Drug Metabolism Mechanisms of Metabolic Drug–Drug Interactions Mechanism-Based Approach for Evaluation of Drug–Drug Interaction ...
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. ...
Journal of Labelled Compounds and RadiopharmaceuticalsWesley A. TurleyRichard C. BurrellSamuel J. Bonacorsi JrAngela K. GoodenoughJoelle M. Onorato
St. John's wort, antidepressant in drug–herb interactionsSt. John's wort, adverse interaction with anti‐HIV drug metabolized by CYP3A4drug–herbal risk, ginseng, ginkgo biloba, garlic, kavaDasgupta, AmitavaJohn Wiley & Sons, Inc.