Do DPP-4 inhibitors have compelling patient-oriented benefits in the treatment of type 2 diabetes mellitus?Yes. Dipeptidyl peptidase-4 (DPP-4) inhibitors have a low risk of hypoglycemia and decrease the incidence of major adverse cardiovascular events and all-cause mortality compared with placebo ...
Structures were solved using direct methods (SHELXS-97 software package) and refined by full-matrix least-squares F2 (SHELXL-97). The H atom positions were calculated geometrically, and a riding model was applied in the refinement process. The structure of p-Br DPP is deposited under CCDC ...
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Full size image Fig. 3 SL-diet-induced early mortality in db/db mice and DPP-4 inhibition reduced lethality. Survival rates of indicated mice (n = 27). The db/+ and db/db mice were fed the SL diet, SO diet, SL + DPP-4 inhibitor diet, or SO + DPP-4 inhibitor diet, as describ...
Full size table Preclinical effects of DPP4 inhibitor in autoimmune diabetes Administration of DPP-4 inhibitors can inhibit inflammatory signaling pathways [70, 71] mediating vascular smooth cell proliferation and oxidative stress in various cells types [72], and also appears to improve endothelial funct...
Morphogen gradients are fundamental to establish morphological patterns in developing tissues1. During development, gradients scale to remain proportional to the size of growing organs2,3. Scaling is a universal gear that adjusts patterns to size in livi
Full size image Table 1 Clinical parameters of chronic kidney disease (CKD) rats Full size table Serum DPP-4 level was increased during progression of CKD Serum DPP-4 level was increased in the CKD group, relative to control (2 weeks, 21.1 ± 4.8; 4 weeks, 22.0 ± 6.1...
Evaluation of a non‐invasive device to measure difference in pulse pressure (dPP) intraoperatively ‐ preliminary results: 3AP3‐3An abstract is unavailable.doi:10.1097/00003643-201306001-00135Schnupp, V.Rump, A.Piepho, T.Schmidtmann, I.
Full size table The primary endpoint Change in FMD (ΔFMD) was significantly improved after 12 weeks of treatment in both groups (sitagliptin: +1.11, 95% CI: 0.07-2.16 versus voglibose: +0.98, 95% CI: 0.04-1.91), and there was no significant difference in ΔFMD between the two groups ...
Full size image We then compared the dpp expression levels between left and right sides of the mantle edges using qRT-PCR analysis in the three gastropod species. We again found different expression patterns between the coiled and non-coiled shell of the gastropods, consistent with the gene expre...