No correlation between serum concentration and degree of renal failure was found. The urinary concentrations of active doxycycline were in the same range as those of the serum. Only a small fraction of the daily dose ofdoxycyline was excreted in the urine. The present study supports earlier ...
Doxycycline in renal failure 来自 Semantic Scholar 喜欢 0 阅读量: 16 作者:rnulf Stenbk,Erik Myhre,Bjrn Peter Berdal 摘要: Twelve patients with grossly impaired renal function were studied. Doxycycline in doses of 200 mg. the first day followed by 100 mg. every 24 hours for 6 days was ...
To the Editor.— The temporally related exacerbation of renal failure associated with doxycycline use, as reported by Dr Orr and colleagues in the Archives (138:793-794, 1978), is certainly of interest and importance. However, the report serves to emphasize the caution with which one should in...
in renal failure. Although the plasma elimination half-life is unchanged, the drug appears to accumulate in tissues with increasing renal failure, and it has been suggested that less drug is bound to plasma protein and red cells through competition with other metabolites, which in turn increases ...
–time curve (AUC) are little altered in renal insufficiency, with no evidence of accumulation after repeat dosing, even in anuric patients, evidently as a result of increased clearance through the liver or gastrointestinal tract, since biliary and fecal concentrations increase in renal failure. ...
Renal Rare (0.01% to 0.1%): Increased BUN/blood urea (dose-related) Frequency not reported: Acute renal failure[Ref]Endocrine Rare (0.01% to 0.1%): Microscopic brown-black discoloration of the thyroid gland[Ref]The long-term use of tetracyclines has been associated with microscopic brown-...
Doxycycline is a semi-synthetic derivative of tetracycline family exhibiting an interesting pharmacokinetic profile since no dosage adjustment is required for renal failure. Doxycycline displays good bacteriostatic activity against most bacteria as well as anti-inflammatory activity. Bacterial resistance is main...
The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin. Nephronophthisis, the most common genetic cause of chronic renal failure in children, is a progressive tubulo-interstitial kidney disorder that is inherite... Mollet,Géraldine,Salomon,......
Methoxyflurane The risk or severity of renal failure can be increased when Doxycycline is combined with Methoxyflurane. Methyldopa Doxycycline may decrease the excretion rate of Methyldopa which could result in a higher serum level. Methylene blue Doxycycline may decrease the excretion rate of Methylen...
it should not be coadministered with these products. Doxycycline is eliminated by nonrenal mechanisms and does not require dose adjustment in renal failure. Doxycycline is generally well tolerated. The most commonside effectsare gastrointestinal, such as nausea, vomiting, and diarrhea. Less common sid...