The primary objective of this study is to evaluate the dose-limiting toxicities (DLTs) and maximum tolerated dose (MTD) or recommended Phase 2 dose (RP2D) of onvansertib in combination with FOLFIRI and bevacizumab (Phase 1b) and to continue to assess the safety and preliminary efficacy of ...
One alternative explanation for the observation that reduced calorie intake elevates H2S levels despite reduced pools of SAAs is that elevation of autophagic processes under nutrient-limiting conditions generates the substrate pool for H2S biogenesis. DR and fasting interventions have been shown ...