Alkylation (烷基烷基化化), Alkylation of guanine by EMS (Ethylmethane sulfonate,甲 8、基磺酸乙酯). O6ethyl-G : TAlkylation 烷化剂烷化剂Although the Watson-Crick face of oxoG is identical to that of guanine and can still base pair with cytosine, it can also rotate around its glycosidic ...
DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy 作者:Yihan PENG, Huadong PEI 摘要:DNA烷基化损伤作为细胞内一种主要的DNA损伤形式,可由外源性化学试剂和内源性代谢物诱导发生。DNA烷基化损伤具有细胞毒性并可能诱导突变,因此烷基化损伤修复在所有细胞内都至关重要。同时,烷基化肿瘤化...
Sequence-specific DNA alkylation targeting for Kras codon 13 mutation by pyrrole- imidazole polyamide seco-CBI conjugates. Chemistry, 2014, 20(5): 1310-1317. 31 Hiraoka K, Inoue T, Taylor R D, et al. Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole ...
DNA烷化剂(Alkylating agent)可将特殊的化学基团添加到DNA上导致DNA烷基化(alkylation,表观遗传修饰)损伤,从而破坏DNA复制和转录,触发细胞周期检查点和/或启动细胞凋亡。如果得不到及时或正确修复,一些损伤就可能导致细胞毒性和/或诱变。在大肠杆菌中,烷基化修复蛋白B(AlkB)可通过消除1-甲基腺嘌呤(1-meA)和3-甲基...
翻译结果1复制译文编辑译文朗读译文返回顶部 端粒DNA的富含G的性质使得它容易受到G-四链的形成,氧化损伤,并通过亲电烷化 翻译结果2复制译文编辑译文朗读译文返回顶部 telomeric DNA 的 G 富人的自然致使它在亲电子试剂旁边易受 G-quadruplex 构成, oxidative 损害, alkylation 的影响 ...
(in which + indicates protonation) and A-UHoogsteen base pairs are strongly disfavored in A-RNA. As a result,N1-methyladenosineandN1-methylguanosine, which occur in DNA as a form ofalkylation damage and in RNA as ...
2.3DNA作为遗传物质 DNA Store information Age:15 Age:45Age:75 Protein Stable Nochange!Nochange!HowcanDNAberesponsibleforthefunctions necessaryofageneticmaterial？AMlUlToAwtiOnmutation Easy replication 1.Storinginformation/保存信息 ADNAstrandhasbasesequences.Basescanbeusedtocodeforaminoacids.Eachaminoacidis...
AlkB是一种α-酮戊二酸(α-Ketoglutarate, α-KG)和Fe(II)依赖的双加氧酶(Dioxygenase),可以有效地修复单链或双链DNA和RNA中的各种烷基化损伤(Alkylation damage),常被用于去除RNA中的m6A等甲基化修饰,去除DNA中的m1A、m3C、m6A等修饰,并进一步用于后续的qPCR或高通量测序分析[1-5]。
Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate CellsJournal of Biological Chemistry (IF 4)Junko Murai, Shar-yin N. Huang, Benu Brata Das, Thomas S. Dexheimer, Shunichi Takeda, Yves Pommier Pub Date: 2021-01-04...