Alkylation (烷基烷基化化), Alkylation of guanine by EMS (Ethylmethane sulfonate,甲 8、基磺酸乙酯). O6ethyl-G : TAlkylation 烷化剂烷化剂Although the Watson-Crick face of oxoG is identical to that of guanine and can still base pair with cytosine, it can also rotate around its glycosidic bo...
DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy 作者:Yihan PENG, Huadong PEI 摘要:DNA烷基化损伤作为细胞内一种主要的DNA损伤形式,可由外源性化学试剂和内源性代谢物诱导发生。DNA烷基化损伤具有细胞毒性并可能诱导突变,因此烷基化损伤修复在所有细胞内都至关重要。同时,烷基化肿瘤化...
翻译结果1复制译文编辑译文朗读译文返回顶部 端粒DNA的富含G的性质使得它容易受到G-四链的形成,氧化损伤,并通过亲电烷化 翻译结果2复制译文编辑译文朗读译文返回顶部 telomeric DNA 的 G 富人的自然致使它在亲电子试剂旁边易受 G-quadruplex 构成, oxidative 损害, alkylation 的影响 ...
(alkylation),一些活性氧(纯态氧、过氧化氢物自由基、过氧化氢,羟自由基),活性氧能对碱基进行化学修饰,最普通的例子是胸腺嘧啶变成胸腺乙二醇(图5-3)(oxi 6、dation) 。,光损伤: 细胞受到 X 光、紫外线照射后,其能量能使DAN发生一些化学反应,最常见的是产生一个新的化学键而形成环丁烷嘧啶二聚体(...
DNA烷化剂(Alkylating agent)可将特殊的化学基团添加到DNA上导致DNA烷基化(alkylation,表观遗传修饰)损伤,从而破坏DNA复制和转录,触发细胞周期检查点和/或启动细胞凋亡。如果得不到及时或正确修复,一些损伤就可能导致细胞毒性和/或诱变。在大肠杆菌中,烷基化修复蛋白B(AlkB)可通过消除1-甲基腺嘌呤(1-meA)和3-甲基...
2.3DNA作为遗传物质 DNA Store information Age:15 Age:45Age:75 Protein Stable Nochange!Nochange!HowcanDNAberesponsibleforthefunctions necessaryofageneticmaterial？AMlUlToAwtiOnmutation Easy replication 1.Storinginformation/保存信息 ADNAstrandhasbasesequences.Basescanbeusedtocodeforaminoacids.Eachaminoacidis...
DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are oxidation, alkylation, hydrolysis and mismatc...
DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are oxidation, alkylation, hydrolysis and mismatc...
(in which + indicates protonation) and A-UHoogsteen base pairs are strongly disfavored in A-RNA. As a result,N1-methyladenosineandN1-methylguanosine, which occur in DNA as a form ofalkylation damage and in RNA as ...
MMR)是指由特异修复DNA碱基错配的酶分子组成.这套系统的存在，可保证遗传物质的完整性和稳定性，避免遗传物质的突变产生，保证DNA复制的高保真度.1993年Fisheletal克隆到第一个人类MMR基因-hMSH2.hMSH2位于人类染色体2p21-22，其基因组全长73kb，含16个外显子，cDNA全长3111bp含有2727的开放阅读框架，翻译后...