Heritable diseases can be broadly classified as diseases that are known to have a genetic component. This genetic component can be the sole determinant of disease, or it may be responsible for only a fraction of the disease susceptibility.
While there may be some situations in vivo where axons are exposed to high concentrations of hydrogen peroxide or other ROS [25], in most diseases that have an inflammatory component axons are likely to be chronically exposed to modestly increased levels of ROS. It remains to be seen if the...
While there may be some situations in vivo where axons are exposed to high concentrations of hydrogen peroxide or other ROS [25], in most diseases that have an inflammatory component axons are likely to be chronically exposed to modestly increased levels of ROS. It remains to be seen if the...
These disorders, which usually have a psychological component,... mental disorder Mental disorder, any illness with significant psychological or behavioral manifestations that is associated with either a painful or distressing symptom or an impairment in one or more important areas... renal system...
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Among these mendelian forms of hereditary parkinsonism is also the parkinsonism with the “typical” phenotype, listed under the gene name LRRK2. Despite the phenotypic homogeneity of LRRK2 parkinsonism, 6 types of pathological findings have been reported in association with this phenotype so far. ...
a systemic disease, can also manifest as different local maladies, all of which may lead to anaphylactic shock in severe cases. The incidence of allergic diseases is high, bringing much suffering to patients. It is estimated that nearly 500 million and 300 million individuals worldwide have AR ...
The term corneal dystrophy embraces a heterogenous group of bilateral genetically determined non-inflammatory corneal diseases that are restricted to the cornea. The designation is imprecise but remains in vogue because of its clinical value. Clinically,
a potentially life-threatening infection. The latter is mostoften associated with infection byHaemophilus influenzae,Neisseria meningitidis, orStreptococcus pneumoniae. Other bacterial infections that have clear neuropsychiatric manifestations include those associated with neurosyphilis (general paresis) and Lyme ...
A huge leap toward developing CRISPR-based molecular diagnostics was the discovery of protein collateral activity of Cas12, Cas13, and Cas14, a property that can be harnessed to amplify the specific on-target signal [43]. Today, many modifications and improvements have been introduced into ...