Parkinson's disease (PD) is one of the most common neurodegenerative disorders, affecting about 1% of the population over the age of 60. In addition to motor abnormalities, there are several non-motor signs and symptoms that may create a considerable burden for patients and care-givers. ...
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder (1). Neuropathologically, it is defined by nerve cell loss in the substantia nigra and the presence of Lewy bodies and Lewy neurites (2,3). In many cases, Lewy bodies are also found in the dorsal motor nuc...
Parkinson’s disease dementia is associated with reduced attention and a decline in executive function skills as well as neuropsychiatric symptoms, such as reduced ability to take initiative and changes in mood. Dementia with Lewy bodies is characterised, in addition to cognitive symptoms, by recurring...
Parkinson's disease (PD) is a neurodegenerative disorder; along with its well-known motor symptoms, it leads to cognitive impairment, behavioral symptoms, and autonomic dysfunction. Dementia is highly prevalent in PD (PD-D), especially in the advanced stages of the disease. The cognitive profile...
…Lewy bodies is related to Parkinson disease dementia (PDD), in that both are associated with the accumulation of so-called Lewy bodies—abnormal deposits of a protein known as alpha-synuclein—in the brain. Lewy bodies are named for German physician Friedrich Heinrich Lewy, who first described...
Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from the brainstem to limbic and neocortical structures seems to be the strongest neuropathological correlate of emergi...
The prevalence of dementia, assessed on the basis of the Wechsler scale (WAIS), was determined in a group of 88 patients with idiopathic Parkinson's disease (PD) lasting longer than 4 years. In this group, 19 patients (22%) were diagnosed as demented. They were significantly older...
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson’s disease and dementia with Lewy bodies. They are made of ab... MG Spillantini,RA Crowther,...
帕金森病痴呆Dementia with Parkinson's disease,PDD 病例 •男性，68岁，肢体不自主抖动6年；行动迟缓，行走困难1年特点：–进行性加重–症状自左手开始，逐渐发展至右侧肢体–肢体抖动静止时明显，情绪激动、紧张时加重–肢体灵活性差，穿衣、系扣、系鞋带均有不同程度的困难–行走困难，身体前倾，步距小，拖步，...
Lewy body cortical involvement may not always predict dementia in Parkinson's disease. The presence of Lewy bodies (LB) in the neocortex and limbic system in patients with Parkinson's disease (PD) is commonly thought to be linked with cogniti... Colosimo,C - 《Journal of Neurology Neurosurger...