De novo Peptide Design* Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).Online InquiryDe novo design is an attractive approach for constructing designed peptides with predetermined structures and functions. Creative Peptides ...
In recent years our ability to design and assemble peptide-based materials and objects de novo(i.e.from first principles) has improved considerably. This brings us to a point where the resulting assemblies are quite sophisticated and amenable to engineering in new functions. Whilst such systems ...
5.3.2De novopeptide design For computational chemists, realizing the automation of peptide design has always been a great goal solving the problem of discovering and synthesizing peptides that are expensive and time-consuming. Aside from docking andvirtual screening,de novodesign of peptides has been...
De Novo Design of Peptide Scaffolds as Novel Preorganized Ligands for Metal-Ion CoordinationDe Novo Design of Peptide Scaffolds as Novel Preorganized Ligands for Metal-Ion CoordinationDe novo peptide designCoiled coilα-helixCoordination chemistryMetal...
β-sheet proteins carry out critical functions in biology, and hence are attractive scaffolds for computational protein design. Despite this potential, de novo design of all-β-sheet proteins from first principles lags far behind the design of all-α or
`De novo' engineering of peptide immuno- genic and antigenic determinants as potential vaccines. In: Basava C, Anantharamaiah GM (eds). Peptides: Design, Synthesis and Biological Activity. Birkhauser: Boston, 1994, pp 133-164.De Novo " Engineering of Peptide Immunogenic and Antigenic Determinants...
We posed the challenge of de novo protein design in the online protein-folding game Foldit5. Players were presented with a fully extended peptide chain and challenged to craft a folded protein structure and an amino acid sequence encoding that structure. After many iterations of player design, ...
The α-helix is pre-eminent in structural biology1 and widely exploited in protein folding2, design3 and engineering4. Although other helical peptide conformations do exist near to the α-helical region of conformational space—namely, 310-helices and π
single chain precursors. In this work, we developed a unique, efficient, and convenient interchain disulfide pairing strategy to direct peptide heterodimerizations. By combining the disulfide pairing chemistry with de novo protein design, we can exploit the dimeric structure space for designing peptide ...
摘要: Recent advances in the field of de novo protein design are examined. The data are examined with respect to the hypothesis that most designed proteins exhibit characteristics similar to those of molten globules. Continuing efforts to produce novel proteins with the specific interactions that defi...