The authors developed a method to synthesize and screen large libraries of small cyclic peptides while enabling the simultaneous interrogation of activity and permeability. This approach was applied to the disease target thrombin to discover peptides with high affinity, stability and oral bioavailability...
De novo development of small cyclic peptides that are orally bioavailable Manuel L. Merz Sevan Habeshian Christian Heinis Nature Chemical Biology(2024) Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors Zeyu Qiao ...
single chain precursors. In this work, we developed a unique, efficient, and convenient interchain disulfide pairing strategy to direct peptide heterodimerizations. By combining the disulfide pairing chemistry with de novo protein design, we can exploit the dimeric structure space for designing peptide ...
Cyclic peptides discovered by genetically encoded library technologies have emerged as a class of promising molecules in chemical biology and drug discovery. Here we review the cyclic peptides identified through these techniques reported in the period 2015 to 2019, with a particular focus on the ...
developed methods; R.S. and S.L. developed de novo folding protocol; S.L. developed high-resolution refinement protocol, performed benchmark and experimental model building; P.L.S. and J.M. designed research; S.L., P.L.S., and J.M. wrote the paper. Supplemental Data Download: ...
ato these systems have involved the de novo generation of the het-erocyclic core with suitably functionalized precursors that allow 对这些系统涉及de杂环核心的世代与适当地functionalized前体允许的novo[translate]
pepfoldnovopredictionserverupdated PEP-FOLD:anupdateddenovostructurepredictionserverforbothlinearanddisulfidebondedcyclicpeptidesPierreThe´venet1,2,3,YiminShen1,2,JulienMaupetit1,2,4,Fre´de´ricGuyon1,2,PhilippeDerreumaux2,3,5andPierreTuffe´ry1,2,4,*1INSERM,U973,MTi,2UnivParisDiderot,Sor...
The genome of Castellaniella defragrans 65Phen was sequenced at the Max Planck Genome Center in Cologne, using the PacBio SMRT system (Pacific Biosciences, Menlo Park, CA). 19858 quality-checked error-corrected reads with at least 4975 bases were de novo assembled to a single contig. The ...
Devices described herein include silicon plates having a plurality of channels in fluid communication with a plurality of microchannels. The number of microchannels and dimensions of the microchannels provide for rapid exchange of chemical exposure during de novo synthesis of oligonucleic acids....
2. The method of claim 1, wherein said ligands comprise at least one of (i) ligands which occur naturally in a biological system such as metabolites, peptides, lipids and nucleic acids including small RNAs and oligonucleotides, (ii) test compounds, (iii) ligands having a molecular mass betw...