Although available treatments for Huntington’s disease (HD) are imperfect, thoughtful application can positively impact quality of life. Dopamine ant
Huntington''s disease is a progressive neurodegenerative disorder for which therapies are woefully inadequate and do not prevent inevitable progression. Currently approved therapies are primarily aimed at treating chorea, but do not address the more clinically meaningful motor, behavioral, and cognitive ...
Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease Huntington disease (HD) is a dominantly inherited progressive neurological disease characterized by chorea, an involuntary brief movement that tends to flo... S Frank - 《Neuropsychiatric Disease ...
, but other analyzed disorders also included Edwards syndrome, Patau syndrome, Klinefelter syndrome, Turner syndrome, Di George syndrome. Moreover, rare diseases such as myotonic dystrophy 1, Huntington’s disease, and fragile X syndrome were studied. The details are shown inSupplementary Table S1....
Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia Jian-kang Hu Xin Tang Qiu-ping Xiang Article31 Jan 2025 Author Correction: THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-...
Abstract The thalamus provides a nodal link for multiple functional circuits that are impaired in schizophrenia (SZ). Despite inconsistencies in the literature, a meta analysis suggests that the volume of the thalamus relative to that of the brain is decreased in SZ. Morphometric neuroimaging studies...
Psychiatric morbidity constitutes such a significant component of Huntington's disease (HD) that it should be defined as a neuropsychiatric disorder. Current epidemiological data often do not do justice to the true prevalence of psychiatric complaints, particularly when classification systems are used (e...
Huntington's Disease is one of the well-studied neurodegenerative conditions, a quite devastating and currently incurable one. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. This results in ...
Huntington's disease (HD) clinical manifestations begin insidiously and are progressively incapacitating. Symptomatic therapies, in particular dopamine blockers and neuroleptics, are presently the only treatment for HD. Identification of neuropathological mechanisms that underlie the selective striatal and ...
diseasemutanthuntingtinneuroprotectivetherapysymptomatictreatmentHuntington's disease (HD) clinical manifestations begin insidiously and are progressively incapacitating. Symptomatic therapies, in particular dopamine blockers and neuroleptics, are presently the only treatment for HD. Identification of neuropatholog...