近日,来自韩国首尔大学医院生物医学研究所的研究者们在Mol Ther杂志上发表了题为“Defining mesenchymal stem/stromal cell-induced myeloid-derived suppressor cells using single-cell transcriptomics”的文章,该研究揭示了间充质干细胞诱导的髓源性抑制细胞的独特转录谱,并确定CSF-1R是检测和治疗富集髓源性抑制细胞的...
C., Tabar, V., et al. (2020). Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells.Cell181, 1643–1660.e17. https://doi.org/10.1016/j.cell.2020.05.007...
Figure3. Detect Luciferase assay by Promega Bright-Glo Luciferase Assay System. HEK293/CFS1R-SRE Luciferase Reporter cells were stimulated by CSF1, the EC50 was 3.75ng/ml. Figure4. HEK293/CFS1R-SRE Luciferase Reporter cells were stimulated by CSF1 inhibitors. 3.HEK293-CSF1R Figure5. Recomb...
虽然CD47抗体可以重新唤醒巨噬细胞,但是肿瘤浸润区的巨噬细胞更多是发挥免疫抑制作用。尤其是MDSCs (myeloid-derived suppressor cells),可以通过高表达CSF1R来促使巨噬细胞选择性忽视肿瘤细胞的存在。CSF1R在健康组织中协助巨噬细胞抑制受损组织处的免疫反应,同时通过促进血管再生来加速愈合。但是在癌症中这个功能却被用来...
CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic...
尤其是MDSCs (myeloid-derived suppressor cells)，可以通过高表达CSF1R来促使巨噬细胞选择性忽视肿瘤细胞...
原始出处:David K. Edwards V,et al.CSF1R inhibitors exhibit anti-tumor activity in acute myeloid leukemia by blocking paracrine signals from support cells. Blood 2018 :blood-2018-03-838946; doi: https://doi.org/10.1182/blo...
AFS98-CP131单克隆抗体能与小鼠集落刺激因子1受体(CSF1R),也称为巨噬细胞集落刺激因子受体(M-CSFR),即CD115反应。CSF1R是一种单程I型膜蛋白,是血小板衍生生长因子受体家族的成员。在小鼠中,CSF1R由单核细胞/巨噬细胞、腹膜渗出物细胞、浆细胞样和常规树突细胞以及破骨细胞表达。CSF1R是CSF1的受体,CSF1通过CS...
proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first...
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