Background: Cryptococcus neoformans infection is a common fungal infection that is cosmopolitan in distribution and causes a life-threatening disease..Baba Waru GoniIbrahim Musa KidaIsmaila Adamu SaiduHaruna YusuphMichael BrownBukar BakkiBabajide Ajayi...
Among pathogenic fungal protein kinases, CMGC, CAMK, STE and AGC kinases appear to be the most common clades (Fig. 1c). Construction of the C. neoformans kinase mutant library. To gain insights into the biological functions of Cryptococcus kinome networks, we aimed to construct gene-deletion ...
neoformans TF phenome database (http://tf.cryptococcus.org). In conclusion, our phenome-based functional analysis of the C. neoformans TF mutant library provides key insights into transcriptional networks of basidiomycetous fungi and human fungal pathogens. 1 Department of Biotechnology, Center for ...
neoformans cells were recovered from the lung tissue. Quantitative PCR using tag-specific primers together with a common primer in the gene deletion cassette was used to measure the relative abundance of each mutant in both the input and recovered pools. The ratio of these two values ([...
Laurenson IF, Lalloo DG, Naraqi S et al (1997) Cryptococcus neoformans in Papua New Guinea: a common pathogen but an elusive source. J Med Vet Mycol 35:437–440 Article PubMed CAS Google Scholar Lazera MS, Wanke B, Nishikawa MM (1993) Isolation of both varieties of Cryptococcus neofor...
The genus Cryptococcus is well known for its two species 鈥 Cryptococcus neoformans and C. gatii 鈥攖hat are etiological agents of cryptococcosis,an important fungal disease of mammals, including humans, and which is particularly common in immunocompromised patients. Nevertheless, Cryptococcus is a ...
There are approximately 1 million cryptococcal infections per year among HIV+ individuals, resulting in nearly 625,000 deaths. Cryptococcus neoformans and Cryptococcus gattii are the two most common species that cause human cryptococcosis. These two spec
plant defensin; javanicin; Cryptococcus neoformans; antifungal action; proteomics1. Introduction The number of immunocompromised individuals including patients with organ transplantations, AIDS, as well as people living with cancer and receiving chemotherapy is increasing worldwide [1]. These individuals ...
neoformans infection models. Keywords: Cryptococcus neoformans; inbred mouse models; host immune responses; host–pathogen interactions; cryptococcal meningitis; cryptococcal immune reconstitution inflammatory syndrome; latent C. neoformans infection; damage-response framework; fungus; human fungal pathogen...
Yeast strains: Cryptococcus neoformans var grubii (strain H99) (serotype A, MATα) and Candida albicans (strain SC5314), used to produce IP3-4K cDNA, were routinely grown on YPD (1% yeast extract, 2% peptone and 2% dextrose). Bacterial strains: One Shot™ TOP10 chemically competent E. ...