Our results suggest that CRY1 fulfills its role as an essential circadian repressor by sequestering the TAD from coactivators, and they highlight regulation of the BMAL1 TAD as a critical mechanism for establishing circadian timing.This is a preview of subscription content, access via your ...
Here, the circadian factor CRY1, an evolutionally conserved transcriptional coregulator, is identified as a tumor specific regulator of DNA repair. Key findings demonstrate that CRY1 expression is androgen-responsive and associates with poor outcome in prostate cancer. Functional studies and first-in-...
Understanding the function of PAR domain protein1epsilon and cryptochrome within the Drosophilia melanogaster circadian clockMolecular biologyNeurosciences Understanding the function of PAR domain protein1epsilon and cryptochrome within the Drosophilia melanogaster circadian clock UNIVERSITY OF HOUSTON Benito...
CRY1 and CRY2 negatively regulate SCN components by associating with the activators Clock-BMAL1, and also with the various feedback inhibitors Per1, Per2 and Tim.Function : Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCKNPAS2-ARNTL E box-mediated transcription. ...
Cryptochrome 1 (CRY1)Cell culture studies identified a small molecule circadian rhythm regulator that could help treat diabetes. Further details on the research, next steps and licensing status are discussed in the article.Science-Business eXchange...
Cryptochrome 1 (CRY1)Cell culture studies identified a small molecule circadian rhythm regulator that could help treat diabetes.SciBX: Science-Business eXchangedoi:10.1038/scibx.2010.1117None
the activators Clock-BMAL1, and also with the various feedback inhibitors Per1, Per2 and Tim.Function : Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCKNPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and ...
circadian genes including the cryptochrome circadian regulator 2 (CRY2), neuronal PAS domain protein 2 (NPAS2), circadian associated repressor of transcription (CIART), aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), period circadian regulator 1 (PER1) and period circadian regulator ...
LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 form a positive feedback regulatory loop in the Arabidopsis circadian clock. Plant Cell 23, 486–498 (2011). Article CAS PubMed PubMed Central Google Scholar Wu, J. F., Wang, Y. & Wu, S. H. Two new clock proteins, LWD1 and LWD2...
as both are bound either directly or indirectly to the core regulator COP1 (E3 ubiquitin ligase)2,39. Since cryptochromes bind to COP1 independently of light, they would be in permanent close proximity to the G-box binding family of transcription factors, which bind to COP1 through the inter...