基因名全称cryptochrome circadian clock 1 蛋白名全称Cryptochrome-1 推荐稀释比 Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of...
The mammalian circadian clock is a global regulatory system that controls many aspects of physiology, including behavior, metabolism, cell cycle progression, and overall fitness. CRYPTOCHROMES (CRYs) are core elements of the mammalian circadian clock, and loss of CRY expression leads to arrythmicity....
Also found in:Medical,Wikipedia. cryptochromes [′krip·tə‚krōm] (cell and molecular biology) Light-sensitive proteins found in both plants and animals that detect and change conformation in response to blue light; in animals, they play an important role in circadian rhythm. ...
Cryptochrome 1 (CRY1) is well known as a circadian clock repressor. Recent studies have shown that it could intimately associate with nuclear receptors and either activate or inhibit its targets at the transcriptional level. In the present study, we applied publicly available transcriptional factors ...
Circadian rhythms influence many behaviours and diseases1,2. They arise from oscillations in gene expression caused by repressor proteins that directly inhibit transcription of their own genes. The fly circadian clock offers a valuable model for studying these processes, wherein Timeless (Tim) plays ...
The molecular circadian clock in mammals is generated from transcriptional activation by the bHLH-PAS transcription factor CLOCK–BMAL1 and subsequent repression by PERIOD and CRYPTOCHROME (CRY). The mechanism by which CRYs repress CLOCK–BMAL1 to close the negative feedback loop and generate 24-h ...
%Cryptochrome(cry)is clock gene involved in the regulation of circadian rhythms in most organisms. In the present study,two cry genes(named as Cs - cry1 and Cs - cry2,Genbank ID:HG780135 and KF977409, respectively)were cloned from Chilo suppressalis. Cs - cry1 and Cs - ...
Both mRNA and protein levels of circadian clock gene Cryptochrome1 (Cry1) were markedly decreased in CIA + MEL group compared with those in control and CIA groups. MLT increased paw thickness. Histologic and X-ray assessment also revealed increased infiltration of inflammatory cells, synovial ...
Cryptochrome(cry)is clock gene involved in the regulation of circadian rhythms in most organisms. In the present study,two cry genes(named as Cs - cry1 and... 刘苏,安徽农业大学 植物保护学院,张胜利,... 被引量: 0发表: 2014年 二化螟隐花色素基因 cryptochrome1和 cryptochrome2的克隆与表达谱分...
Although most circadian clock components are conserved between Drosophila and mammals, the roles assigned to the CRYPTOCHROME (CRY) proteins are very different: Drosophila CRY functions as a circadian photoreceptor, whereas mammalian CRY proteins (mCRY1 and 2) are transcriptional repressors essential for...