As shown in our control treatments, technical limitations and difficulties in single-cell isolation can produce false-positive heteroplasmy readouts due to extracellular mtDNA contamination. Although critical for detection of heteroplasmic cells, our chimera approach is not suitable for identification the ...
There is a growing body of scientific research showing the link between depression and dementia in Alzheimer’s disease (AD). The chronic stress contributes to the formation of oxidative stress in the parts of the brain involved in the development of depression and AD. The scientific literature ...
Multiple neurodegenerative diseases (NDDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD) are being suggested to have common cellular and molecular pathological mechanisms, characterized mainly by protein misfolding and...