A mathematical model was used by researchers to assess the costs of adjuvant chemotherapy for colon cancer. Results revealed that FOLFOX-4 is the most expensive chemotherapy regimen, while capecitabine is the cheapest. Drug acquisition prices were said to be responsible for about 90% of the total...
834), based on 3-year disease-free survival (DFS), showed that FOLFOX narrowly failed to meet the prespecified noninferiority threshold. The 3-year DFS in the FOLFOX 3-month arm was lower than that in the 6-month arm by 0.9% (hazard ratio [HR], 1.07; 95% confidence interval [...
FOLFOX4 in the treatment of metastatic colorectal cancer in elderly patients: A prospective study Elderly patients constitute a subpopulation with special characteristics that differ from those of the general population and have been under-represented i... M Berretta,A Cappellani,F Fiorica,... - ...
AIM:To compare XELOX and FOLFOX4 as colon cancer adjuvant chemotherapy based on MOSAIC and No.16968 trails from Chinese cost-effectiveness perspective.METHODS:A decision-analytic Markov model was developed to compare the FOLFOX4 and XELOX regimens based MOSAIC and No.16968 trial.Five states were in...
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet, 355: 1041–1047, 2000 Article PubMed CAS Google Scholar Tournigand C, Andre T, Achille E, et al. FOLFIRI followed by FOLFOX6 ...
DS-7423 Phase 1 mTOR/PI3K inhibitor in treatment of colon cancer and endometrial cancer Nonrandomized Completed https://clinicaltrials.gov/ct2/show/NCT01364844?term = mtor&cond = Colon + Cancer&draw = 1&rank = 8 RAD001 (Everolimus)In combination with FOLFOX, Bevacizumab Phase ...
Lee et al. BMC Cancer (2024) 24:397 https://doi.org/10.1186/s12885-024-11939-x BMC Cancer STUDY PROTOCOL Open Access mFOLFIRINOX versus mFOLFOX 6 as adjuvant treatment for high-risk stage III colon cancer - the FROST trial: study protocol for a multicenter, randomized controlled, phase ...
Two large randomized trials (MOSAIC and NASBP-C06) investigated the addition of oxaliplatin to fluorouracil (FOLFOX4 and FLOX, respectively) and demonstrated a significant improvement in 3-year disease-free survival for patients with stage III colon cancer. The addition of irinotecan to fluorouracil ...
Repression of cell cycle-related proteins by oxaliplatin but not cisplatin in human colon cancer cells. Mol Cancer Ther 2006;5:2149-57... Voland,C. - 《Molecular Cancer Therapeutics》 被引量: 136发表: 2006年 5-fluorouracil leucovorin and oxaliplatin (FOLFOX) in the treatment of metastatic colo...
The results of the MOSAIC trial demonstrated the benefit of adding oxaliplatin to 5-fluorouracil (5-FU) and leucovorin ( FOLFOX ) in adjuvant therapy for stage II and III disease, but the optimal duration of therapy and the management of toxicities remain to be resolved. Capecitabine is at ...