CAS号: 英文名: CLK inhibitor T3 英文别名: CLK inhibitor T3 中文名: CLK INHIBITOR T3(T3) 中文别名: CBNumber: CB84667759 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 0 CLK INHIBITOR T3(T3)化学性质 ...
SM08502 is a first-in-class CLK inhibitor being investigated in a Phase 1 clinical trial for subjects with advanced solid tumors.doi:10.1016/j.canlet.2019.09.009Betty Y. Tam aKevin Chiu bHeekyung Chung bCarine Bossard bJohn Duc Nguyen a...
At 1nM OA, neurite outgrowth was rescued by co‐treatment with a novel CLK inhibitor (two﹚ay ANOVA, p<0.0001). Novel CLK inhibitors can modulate the expression of MAPT splicing isoforms and exert a functional effect on neurite outgrowth. This suggests these compounds could have a therapeutic ...
Increased breast cancer cell sensitivity to cisplatin using a novel small molecule inhibitor. J Cancer Res Ther. 2020;16:1393–401. CAS PubMed Google Scholar Hill DP, Harper A, Malcolm J, McAndrews MS, Mockus SM, Patterson SE, et al. Cisplatin-resistant triple-negative breast cancer ...
[1].Betty Y Tam, et al. The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models. Cancer Lett. 2020 Mar 31;473:186-197.[Content Brief] 完整储备液配制表 *请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶...
生化机理 CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC 50 s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity. 储存温度 -20°C储存 运输条件 超低温冰袋运输 ...
We previously showed that targeting SRPK splice factor kinases in prostate cancer cells could could provide a novel therapeutic strategy11. Here we have targeted CLKs in prostate cancer cells with the benzothiazole TG003, a well-established small molecule inhibitor of CLK1 and CLK431. We find th...
CLK1-IN-2, a metabolically stable Clk1 inhibitor, exhibits selective activity for Clk1 with an IC50 value of 1.7 nM. It is applicable in researching tumor, Duchenne's muscular dystrophy, and viral infections including HIV-1 and influenza. 化学信息 分子量 367.25 分子式 C16H12Cl2N2O2S 储存&溶...
CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity. 靶点活性 CLK3:110 nM, CLK2:15 nM, CLK1:0.67 nM 体外活性 CLK-IN-T3 (0.5, 1.0 μM) decreases the phosphorylation of CLK-targeted SR proteins and ...
ML167是一种高度选择性的Cdc2样激酶4(Clk4)抑制剂,IC50为136nM,比作用于相关激酶Clk1,Clk2,Clk3和Dyrk1A/1B的选择性高10多倍。注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!CAS号:1285702-20-6别名:CID44968231;NCGC00188654纯度:98.51%分子式:C19H17N3O3分子量:335.36结构式:储存条件:-20℃,有效...