Skin homing CD4+CLA+ T cells from AD patients showed significant differences in DNA methylation in 40 genes compared to HC (p < 0.05). Reduced DNA methylation levels in the upstream region of the interleukin-13 gene (IL13) in CD4+CLA+ T cells from AD patients correlated with increased IL...
There are T cells within normal, noninflamed skin that most likely conduct immunosurveillance and are implicated in the development of psoriasis. We isolated T cells from normal human skin using both established and novel methods. Skin resident T cells expressed high levels of CLA, CCR4, and CCR...
CLA能通过调控脂肪酸合成相关的酶或受体的表达抑制脂肪酸合成,从而减少脂肪生成;在脂肪酸转运到前脂肪细胞中进一步合成甘油三酯的过程中,CLA通过抑制PPARγ 激活物的形成抑制脂蛋白酯酶(LPL)的表达,减少脂肪酸进入前脂肪细胞;CLA可通过抑制SREBP1的表达来减少磷酸甘油脱氢酶含量,抑制α-磷酸甘油的生成[13];CLA(t10,c1...
Sigmundsdottir H.Gudjonsson JE, Jonsdottir I et al.The frequency of CLA+CD8~+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease. Clinical and Experimental Immunology . 2001Sigmundsdottir H, Gudjonsson JE, Jonsdottir I, et al. (2001)...
CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cellsT. G. Moreira, L. S. Horta, A. C. Gomes-Santos, R. P. Oliveira, N. M. G. P. Queiroz, D. Mangani, B Daniel, A. T. Vieira, S. Liu, A. M. ...
Carnitine is an amino acid that is crucial to our functioning bodies. Carnitine is shown to help the body transport fatty acids to our cells to be used as energy. Then to really give that boost we added Green Tea, Black Tea, and White Tea extract aimed at kickstarting your bodies thermog...
Upon activation, T cells upregulate cell-surface molecules that enable entry into peripheral tissues. Retinoic acid (RA) produced by gut DC induces integrin α4β7 required for gut homing and represses CLA which facilitates skin entry; hence, these markers are usually reciprocally expressed. We ...
[8]Lau DS, Archer MC. The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells. Nutr Cancer. (2010) [9]Zabala A, et al. trans-10,cis-12 Conjugated linoleic acid inhibitslipoproteinlipase but...
There are two distinct, functionally specialized sets of helper T-cells (Th) that act synergistically in most antibody responses. One of these helper T cells, which is called Th1, is antigen- or carrier-specific and acts via an antigen bridge in activating B cells. The other helper T cell...
图2 模块化CAR-T的设计策略示意图(来源:资料1) 2月初在在纳斯达克上市的Arcellx细胞治疗公司也布局了这一领域的产品。Arcellx的的ARC-sparX Platefrom将T细胞设计ACT-T细胞(antigen receptor complex T cells),同时选用一类无内在治疗活性的可溶性蛋白sparX ...