Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 2010;343(9):489–99. doi:10.1002/ardp.200900319. 6. Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: A review of anti- cancer properties and therapeutic ...
Many drugs target genes that exhibit circadian oscillations, and the pharmacokinetics and pharmacodynamics of these drugs may vary with time (Dallmann et al., 2016). Therefore, understanding the ideal timing for drug administration has the potential to enhance efficacy and reduce side effects. ...
[v]Brodner, D.C., Shah, S.M. (2017, June 3-7). REM Absorption Kinetics Trial: A Randomized, Crossover, Pharmacokinetics Evaluation of a Novel Continuous Release and Absorption Melatonin Formulation versus a Same Strength Immediate-Release Formulation in Healthy Adults (Abstract #0396). Poster...
Cancer cells typically divide with weaker synchronisation with the circadian clock than normal cells, with the degree of decoupling increasing with tumour maturity. Chronotherapy exploits this loss of synchronisation, using drugs with circadian-clock-dep