In true tumor therapy the local "functional organization" of single cell units relative to the whole body is very important, because it reveals the first changes within the internal milieu of an organism. Histomorphologic changes resulting from the organism's reduced regulative capacity begin in ...
导读:本文是针对论文《利用细胞因子和趋化因子治疗癌症(Harnessing cytokines and chemokines for cancer therapy)》的一篇解析,该论文于2022年4月发表于《Nat RevClin Oncol(IF: 66.7)》。 综述背景:在过去的40年里,细胞因子和细胞因子受体作为癌症靶标或癌症治疗手段被广泛研究。但是许多挑战仍然存在,特别是关于给药...
Close monitoring for these potential adverse effects is an essential part of any treatment plan involving these drugs to help mitigate discomfort and long-term complications. 4 Reference 1. Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014...
祝贺温龙平教授和张云娇教授受邀在国际顶级期刊《Accounts of Chemical Research》(影响因子21.661)发表题为《Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy》,系统综述了研究团队近15年来在纳米材料诱导细胞自噬调控细胞命运的效应、机制及肿瘤治疗...
7月3日，清华联合北大在《Nature Chemical Biology》上发表了名为“Dissolution of oncofusion transcription factor condensates for cancer therapy”的研究论文，该研究全面审查了在各种癌症中发现的融合蛋白。该研究发现许多融合蛋白由相分离倾向域(PS)和DNA结合域(DBDs)组成，这些融合与异常的基因表达模式有很强的相关...
A mutant-selective AKT inhibitor shows potential as a targeted therapy for breast cancer, enabling enhanced target engagement and avoiding the dose-limiting toxicity associated with pan-AKT inhibitors. Gregory B. Craven ,Hang Chu &Jack Taunton ...
There is a pressing need for targeted chemical probes to dissect these complex, interconnected gene regulatory circuits. Validated chemical probes empower mechanistic research while providing the pharmacological proof of concept that is required to translate drug-like derivatives into therapy for cancer ...
Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here we propose a self-deliveringone-componentnew-chemical-entitynanomedicine (ONN) strategy to improve cancer therapy through incorporation of the self-assembly...
Today, treatment methods for cancer—whether surgery, radiation therapy or immunotherapy—are recommended based mainly on the tumor’s location, size and aggressiveness. This information is usually obtained by anatomical imaging—MRI or CT scans or ultrasound and by biological assays p...
In work that heralds a new, more potent form of targeted therapy for cancer, Dana-Farber Cancer Institute scientists have devised a chemical technology that doesn't just disable malevolent proteins in tumor cells, as current agents do, but destroys them. As described in a study posted online M...