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Experimental interventions to modulate cell signalling pathways in long term HFD fed mice often get challenging, costly and time-consuming. Therefore, we opted for well established short term HFD induced IR model in mice31,32. C57BL/6 male and female mice were maintained on HFD diet for one-...
factorThe molecular mechanisms through which oxidized lipids and their electrophilic decomposition products mediate redox cell signalling is not well understood and may involve direct modification of signal-transduction proteins or the secondary production of reactive oxygen or nitrogen specie...
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M. Inflammasomes: mechanism of assembly, regulation and signalling. Nat. Rev. Immunol. 16, 407–420 (2016). CAS PubMed Google Scholar Hari, P. et al. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci. Adv. 5, eaaw0254 (2019). ...
Interestingly this cytokine secretion, which primarily involves IL-6 and IL-8, is only established as a result of persistent DNA damage response signalling (DDR) and not as a result of transient signalling [125] suggesting the presence of long-lived, irreparable DNA lesions are important in ...
The extracellular matrix (ECM) is a dynamic and complex microenvironment that modulates cell behavior and cell fate. Changes in ECM composition and architecture have been correlated with development, differentiation, and disease progression in various pa
This requires a careful whole-cell orchestration of trafficking processes at the levels of membrane, cellular signalling pathways, gene expression programmes and metabolic activity. In a similar fashion, synthetic systems that exploit whole-cell interactions offer exciting opportunities to expand the range...
First, we examined how signalling pathway activity is distributed across the untreated cells of our differentiation system (Extended Data Fig. 4a), revealing expected pathways such as Wnt enriched across stem populations, and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and...
(0.148 in CellAge vs 0.158). CellAge genes were therefore more likely to be bottlenecks in signalling across different modules and occupy localized areas with lower network redundancy, suggesting that perturbations in their expression might have a greater impact on linking different underlying cellular...