We used a cross-correlation matrix to identify predictors of MYC and GREB1 expression, IL-6 secretion, and MCF-7 cell proliferation in response to the 42 diverse compounds in the training set (Table S4). 3xERE-driven ERα activity in HepG2 cells correlated with GREB1 expression. In contr...
response to tat and hiv infection. this work uncovers a previously unrecognised interaction between hiv and its host that may contribute to viral alteration of the host cellular environment. background like all viruses, hiv-1 depends on the internal environment of the host cell to complete its ...
locomotor recovery improved gradually but plateaued after 3 weeks (Fig.1b–d). While mice fed PLX5622 diet recovered similarly to mice fed vehicle diet for 7 dpi, after that they performed worse
explain gene expression changes in response to gene knockouts [8]. Recently, an integrated cellular network of transcription regulation and PPIs was introduced byWangandChen[9,10]. They use gene-expression data at multiple time points to prune and combine candidate gene regulatory and signaling netw...
To evaluate the adaptive immune response differences between young and old individuals after inactivated SARS-CoV-2 vaccine administration, we recruited a cohort of 121 healthy young (18–30 years old) and 48 old (60–85 years old) donors (Supplementary Table1andMethods). For each donor, ...
To test this idea, we inhibited prostaglandin synthesis with CAY or NS in SEN(IR) cells and measured secreted levels of the pro-inflammatory SASP factor interleukin 6 (IL-6) (Figure 4F). Both compounds reduced secreted IL-6 levels (Figure 4F). To assess the effects on other SASP factors...
The virus proteins carry out some functions that depend on interaction with the host cellular proteins, so it is necessary to explore the mechanisms associated with viral pathogenesis and host anti-virus response using a protein interactions approach. The M protein encoded by ORF6 is an un...
Human Immunodeficiency Virus 1 (HIV-1) exhibits a wide range of interactions with the host cell but whether viral proteins interact with cellular RNA is not clear. A candidate interacting factor is the trans-activator of transcription (Tat) protein. Tat
that while NF-κB levels oscillate over a wide range in single cells in response to stimulation, at the population level the response is more homogenous [15]. In contrast to this perspective, emerging results point to the need to consider explicitly the cellular subtypes to account for the ove...
an immune response constitutes the sum of behaviors of cells contributing to an organism’s reaction to a pathogenic microorganism. While this proposition sounds simple, the underlying principle is actually quite complex, because the behavior of immune cells is neither uniform, nor static, nor is it...