After differentiation into preosteoblasts, Runx2, osterix and β-catenin direct the cells to become immature osteoblasts [31]. Osterix (Osx, Sp7), a zinc finger-containing osteoblast-specific transcription factor located in the nucleus, induces the expression of a number of genes involved in the ...
We’re sorry, something doesn't seem to be working properly. Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.Abstract Alkaliptosis is a recently discovered type of pH-dependent cell death used for tumor therapy. However, its underlyi...
12. The T isolated cell of claim 1, wherein the isolated T cell is a primary T cell. 13. An isolated T cell that does not express HLA-A, HLA-B, HLA-C, HLA-DP, HLA-DQ, and HLA-DR and expresses CD47. 14. The isolated T cell of claim 13, wherein the isolated T cell is...
a member of the tumor necrosis factor (TNF) receptor family. Although NTs were first discovered in neurons, recent studies have suggested that NTs and their receptors are expressed
The secretome of cultured PBMCs comprises proteins, lipids, and extracellular vesicles; thus, a multidimensional method- ical approach must be implemented for this type of analysis. To date, several secreted proteins have been identified that exert cytoprotective and regenerative capacities13,14; thus...
Metastatic cancer is rarely cured by current DNA damaging treatments, apparently due to the development of resistance. However, recent data indicates that tumour cells can elicit the opposing processes of senescence and stemness in response to these trea
The semi-quantitative measurements of the immunoreaction of relevant markers for neuronal and glial activity in the SCN have some limitations. While immunohistochemistry has the great advantage that it is restricted to the specific area under investigation and the signal is not “contaminated” by ...
Histone citrullination is a relatively poorly studied epigenetic modification that involves the irreversible conversion of arginine residues into citrulline. It is conferred by a small family of enzymes known as protein arginine deiminases (PADIs). PADI function supports the pluripotent state of embryonic...
Cells that exhibit this level of resistance could have been able to escape immune surveillance and become the origin of the neoplastic process. TRAIL is a type II membrane protein and it is a member of the tumor necrosis factor (TNF) cytokines superfamily. This molecule induces apoptosis upon ...
Studies have described the selective export of toxins and other virulence factors and their transport to host cells via EVs. These EVs may protect toxins and virulence factors from host defenses and allow them to reach host cells more efficiently [17]. It has also been reported that the ...