细胞信号通路Cell Signalling Pathways 下载积分:1000 内容提示: Cell Signalling BiologyMichael J. BerridgerModule 2rCell Signalling Pathways2r1Module 2Cell Signalling PathwaysSynopsisCells use a large number of clearly defined signalling pathways to regulate their activity. In this module,attention is ...
In cancer cells, oncogenic signalling pathways deregulate the activity of the SREBP transcription factors and MVA pathway enzymes. Deregulated production of MVA pathway metabolites modulates multiple signalling pathways in cancer cells and contributes to transformation. Clinical trials to evaluate the utility...
The molecular mechanisms underlying merlin-intact meningioma growth remain to be explored. Here, the authors show that merlin activates Wnt signalling and tumour growth through its dephosphorylation on serine 13 attenuating the inhibitory interactions with β-catenin. ...
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer Nature, 545 (7654) (2017), pp. 360-364 CrossrefView in ScopusGoogle Scholar [57] J. Calbo, E. van Montfort, N. Proost, E. van Drunen, H.B. Beverloo, R. Meuwissen, A. Berns A functional role ...
Mast cells are filled with tiny granules, as you can see in the screenshot of the video below. When they get “angry,” a destabilization process known asdegranulation, they dump up close to 1000 different signalling chemicals—called mediators—into the bloodstream. Those mediators are inflammato...
The signalling pathway Fas and FasL system plays a fundamental role in the regulation of apoptotic cell death and any disturbance of this pathway has been shown to promote immune escape and tumorigenesis. Many types of cancers show reduced expression of FAS and elevated FasL expression. The Fas213...
To further investigate the underlying mechanisms of the observed scCM-induced effects, we evaluated the activation of MAPK, VEGFR2, and PI3K/AKT signalling pathways, key modulators of angiogenesis. scCM induced a strong and consistent ERK1/2 phosphorylation (scCM, 10 min: 2599% [1102–2723]), ...
Damaged mitochondria release mitochondrial ROS and DNA into the cytosol, which acts as danger signals resulting in the hyperactivation of inflammatory signalling pathways [23]. Korski et al. proposed that oxidative stress, mitochondrial dysfunction and cellular energy imbalance could arrest early proliferat...
Rho GTPase signalling in cell migration. Curr. Opin. Cell Biol. 2015, 36, 103–112. [Google Scholar] [CrossRef] [Green Version] Czuchra, A.; Wu, X.; Meyer, H.; Van Hengel, J.; Schroeder, T.; Geffers, R.; Rottner, K.; Brakebusch, C. Cdc42 Is Not Essential for Filopodium...
MicroRNA-1225 activates Keap1-Nrf2-HO-1 signalling to inhibit TNFalpha-induced osteoclastogenesis by mediating ROS generation. Cell Biochem. Funct. 2019, 37, 256–265. [Google Scholar] [CrossRef] Skrzypek, K.; Tertil, M.; Golda, S.; Ciesla, M.; Weglarczyk, K.; Collet, G.; ...