Dementia is a fatal clinical disorder characterised by amnesia, progressive cognitive impairment, disorientation, behavioural disturbance, and loss of daily function; Alzheimer’s disease (AD) is the most common associated pathology. It can be argued that dementia is one of the most significant social...
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Astrocytes, the most numerous cells in the brain, weave the canvas of the grey matter and act as the main element of the homoeostatic system of the brain. They shape the microarchitecture of the brain, form neuronal-glial-vascular units, regulate the blo
The clinical features and pathological findings were consistent with non-Alzheimer dementia with status spongiosus and neuronal cell loss. The unusual perineuronal structures found in our case might be a specific cellular pathology of dementia of the frontal lobe type. 展开 ...
Multiple genetic, metabolic, and environmental abnormalities are known to contribute to the pathogenesis of Alzheimer's dementia (AD). If all of those abnormalities were addressed it should be possible to reverse the dementia; however, that would require a suffocating volume of drugs...
Alzheimer's disease & dementia Immune cells linked to blood vessel damage and neurodegeneration A new study helps explain why having ApoE4—the gene variant most closely linked to Alzheimer's disease—increases the risk of neurodegeneration and white matter damage. ...
zebrafish; human; adult brain; fetal brain; telencephalon; Alzheimer’s disease; single cell RNA sequencing; single nuclear RNA sequencing; astroglia; microglia; neuroregeneration 1. Introduction Alzheimer’s disease (AD) is the most common neurodegenerative disorder and the leading form of dementia ...
Essential oils exhibit numerous medicinal properties, including antimicrobial, anti-inflammatory and antioxidant effects. Recent studies also indicate that certain essential oils demonstrate anti-amyloidogenic activity against β-amyloid, the protein implicated in Alzheimer’s disease. To investigate whether the...
In contrast, most of the individuals who paid higher treatment costs were getting treated for systemic or more complex conditions, such as diabetes,multiple sclerosis (MS), neurodegenerative diseases (such as Alzheimer’s disease or dementia), psoriatic arthritis, orautism. ...
Traumatic brain injury (TBI) is a common trauma with high mortality and disability rates worldwide. However, the current management of this disease is still unsatisfactory. Therefore, it is necessary to investigate the pathophysiological mechanisms of TB