The p19ARF transcript, an alternative spliced form of the CDKN2a gene, has recently been shown to inhibit, like the p16INK4a protein, cell cycle progression, raising the possibility that it might constitute an additional melanoma tumor suppressor gene at the 9p21 locus. To determine the ...
This gene (8.5 kb full length) contains two introns and three exons and encodes the p16INK4a protein. The p16INK4a protein is a protein consisting of 156 amino acids with a molecular weight of 16 kDa and is a negative regulator of the cell cycle (Serrano et al., 1993). In addition...
CDKN2A gene was found to be methylated in 23% of total colorectal cancer patients. The survival data by multivariate analysis can be obtained from three studies (27.3%; Table 1). Five of 11 studies (45.5%) revealed that CDKN2A hypermethylation was a poor prognostic factor for survival of ...
It is probably not a coincidence that CDKN2A/2B is a major tumor suppressor gene target in ferric nitrilotriacetate (Fe-NTA)-induced rat renal carcino- genesis model,33 in which a major mode of inactivation is also homozygous deletion.34,35 In the renal carcinogenesis model, an iron-...
The CDKN2A gene is mapped at the chromosome 9p21 region and encodes the p16INK4A and p14ARF proteins. p16INK4A protein has a key role as negative regulator of the proliferation of normal cells, controlling the progression through G1 into the S phase of the cell cycle. According to Raabe...
From a functional point of view, CDKN2b-AS1 is directly involved in the regulation of gene expression in both cis and trans through its interaction with polycomb repressive complexes 1 and 2 (PRC-1 and PRC-2) [107,108]. CDKN2b-AS1 also possesses miRNA "sponge" functions [109]. Lilly...