VRC被推荐作为绝大多数侵袭性真菌感染(invasive fungal infection,IFI)患者的首选治疗药物。VRC呈非线性药代动力学特征,经细胞色素P450家族(cytochrome P450 proteins, CYP)2C19、CYP3A4等多种亚型代谢,药物相互作用多。本文介绍了药师对1例应用VRC治疗侵袭性...
11. Hałaburda-Rola M, Dzieciątkowski T, Górka M, Rowiński O, Grabowska-Derlatka L. Clinical utility of the updated European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National...
近年来由于造血干细胞移植(HSCT)、实体器官移植得广泛开展、高度免疫抑制剂与大剂量化疗药物得应用以及各种导管得体内介入、留置等,临床上侵袭性肺部真菌感染(invasive pulmonary fungal infections,IPFI)得发病率明显上升。IPFI也日益成为导致器官移植受者、恶性血液病与恶性肿瘤患者以及其她危重患者得死亡原因之一、IPFI得...
woundinfectionsafterminimallyinvasivecoronarybypassprocedures.terofLegionellasternal-woundinfectionsduetopostoperativetopical AnnThoracSurg1998;66:92-4.exposuretocontaminatedtapwater.NEnglJMed1991;324: 10.TheSouthernSurgeonsClub.Aprospectiveanalysisof1518laparo-109-13. scopiccholecystectomies.NEnglJMed1991;324:1073-...
their risk by wearing long sleeves and urged the removal of standing water puddles where mosquitoes lay eggs. Unfortunately, some people who were infected with the virus, especially the neuroinvasive type that could cause swelling of the brain, may feel long-term effects from their infections. ...
Such invasive transition of C. albicans cells is regulated by numerous cell signal transduction pathways, one of which involves a small GTPase, the C. albicans Cdc42 (CaCdcd42), with specific binding to downstream effectors, e.g., CaCla4 and Cst20, containing CRIB domains. Here, we report...
Over the past two decades, about 125 yearly cases of the disease, also referred to astularemia(named afterFrancisella tularensis, the bacterium that causes it), have been reported in the United States. But already this year through September, there have been 100 cases in just four states, acc...
Invasive infections “Typically, fungus and particularly candida species are commensal organisms or organisms that live within us, that live within our guts,” Armstrong said. Infections can occur due to overgrowth, known as candidiasis. If it develops in the mouth or throat, it is called thru...
C. auris "has continued to cause illness and death nationwide." They also said the CDC has rated it as "an 'urgent threat,' the highest level of concern, because it is often multidrug-resistant; spreads easily in healthcare facilities; and can cause severe, invasive infections with high mo...
PTD:posttransplantationday Autopsy(<24hpostdeath):Lung 尸检（死后24h内）：肺 Autopsy(<24h):Heart 尸检（死后24h内）：心脏 Autopsygrossexamandhistopathologydemonstratedangioinvasivefungalinfectioninvolvingthyroid,largeandsmallbowels,kidney,eye,skin,diagram,andskeletalmuscle.尸检大体 和组织病理显示血管侵袭性真菌...