CD56pregnancyfetalIn early pregnancy,the decidua is populated by a large number of natural killer cells(NKs),most of which are CD56bright with a strong capacity to secrete cytokines,differing from peripheral and cord blood NK cells(pNKs and cNKs).1,2,3 It is generally believed that uterine ...
但近年越来越多的研究表明CD56 brightCD16 dimNK细胞亚型在肿瘤的生物学作用中扮演"帮凶"角色,现将近年关于CD56 brightCD16 dimNK细胞在在肿瘤中发挥的效应综述如下。 关键词: NK细胞;TINK;TANK;肿瘤;进展 ABSTRACT Natural Killer (NK) cells can directly kill target cells without pre-sensitization of ...
NK cellsDecidualization denotes the transformation of endometrial stromal fibroblasts into specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix essential for embryo implantation and placental development. In contrast to most mammals, decidualization of the human endometrium ...
In early pregnancy the uterine mucosa, the decidua, is infiltrated by numerous CD56bright, CD16- natural killer (NK) cells. In this paper we have shown that unlike adult peripheral blood NK cells these uterine NK cells express cytoplasmic CD3 and CD3zeta, but CD3gamma and CD3delta were not...
NKtrophoblastsProblem: Decidual natural killer (dNK) cells play key roles in maternal-fetal immune regulation, trophoblast invasion, and vascular remodeling, and most dNK cell populations are CD56bright CD16- NK cells. However, the enrichment and redistribution of dNK cells in the local decidua ...
OBJECTIVE: Human CD56bright CD16- Natural Killer (NK) cells accumulate in the maternal decidua during pregnancy and induce its vascularization by secreting an array of pro-angiogenic factors. These cells differ from the ″classic cytotoxic″ CD56dim CD16+ NK cells, that are immune cells ...
Problem Decidual natural killer (dNK) cells play key roles in maternal‐fetal immune regulation, trophoblast invasion, and vascular remodeling, and most dNK cell populations are CD56 bright CD16 ? NK cells. However, the enrichment and redistribution of dNK cells in the local decidua have not ...
Endometrium or decidua was obtained. The effects of 17beta-estradiol or progesterone (10(-6), 10(-7), and 10(-8) M) on the proliferation, cytolytic activity, and cytokine secretion of the isolated endometrial CD16neg CD56bright NK cells were examined using a 3H-thymidine incorporation assay...
Results suggest that SCF produced in the decidua increases the expression of the IL-2Rα which is usually present in smaller amounts than other two IL-2R chains on decidual CD16−CD56bright NK cells, and thereby promotes the proliferation of these cells in response to low concentrations of...
Natural killer lymphocyte CD3 CD16 CD56+ activity in decidua of women with pregnancy induced hypertensiondoi:10.1016/0143-4004(94)90114-7K. Kaminski and B. Leszczynska-Gorzelak and J. Oleszczuk and D. SzymulaPlacenta