The hematopoietic stem cell (HSC) compartment is heterogeneous, yet our understanding of the identities of different HSC subtypes is limited. Here we show that platelet integrin CD41 (aIIb), currently thought to only transiently mark fetal HSCs, is expressed on an adult HSC subtype that ...
本发明人发现在外周血造血干细胞(HSC)的两步培养中,SR1,一种AhR拮抗剂,显著改善了带有前血小板的MK和血小板样物质的产生。更重要得是,使用SR1的培养得到CD34 + CD41 暗 群的富集,该CD34 + CD41 暗 群通过细胞分选显示出成熟至前血小板阶段的前所未有的能力。 在与人间充质干细胞(hMSC)共培养的HSC中,观察到...
Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Further...
Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Further...
Haematopoiesis in adult animals is maintained by haematopoietic stem cells (HSCs), which self-renew and can give rise to all blood cell lineages. The AGM region is an important intra-embryonic site of HSC development and a wealth of evidence indicates that HSCs emerge from the endothelium of th...
等,证明 了成体 HSC具有 向间质细胞分化 的能力 。 Walenda 和 Balduino等 。 认为造血细胞与问质细 胞的关 系密不可分。Lund等n 通过对斑马鱼的研 究,利用斑马鱼基质细胞模型进一步证 明造血细胞 和问质细胞无论 在体外还是体 内均相互作用。我 ...
的焦点。一些科学家认为永久造血起源于卵黄囊,但近些年的一系列研究表明HSC首 先起源于胚内AGM区。无论是AGM区的永久造血细胞还是YS的永久造血细胞,只 ～ O 内基查医堂院亟±研究生学垡论塞(呈Q!Q生2 有经由循环血(circulatoryblood)迁移至胎肝及以后的造血部位,才对永久造血的维持起 作用。为此,若能在迁移...
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此外,利用独特的阴极和自行合成的N/S共掺杂玉米芯多孔碳(N/S-BPC,1 A g–1时为316.1 F g–1)阳极,开发了一种高性能混合超级电容器(HSC),其在0.75 kW kg–1时的能量密度为68.1 Wh kg–1,具有优异的循环性能。这些发现突出了超高速电池型HSC...