Results: In contrast to T lymphocytes derived from donor mice pretreated with GpG (control)-DNA, CD4+CD62L+ T cells from animals that received CpG-DNA induced a markedly less severe intestinal inflammation when transferred to SCID mice as indicated by lack of clinical signs, histological scores...
调节性T细胞是不同于Thl, Th2和Th17的具有调节功能的T细胞群体,因其具有免疫抑制作用,在自身免疫耐受,获得性免疫耐受以及维持体内的免疫平衡状态中发挥着重要作用.调节性T细胞的种类很多,包括Tr1细胞,natural killer T cells,一小群CD8+T细胞以及CD4+CD25+Foxp3+T细胞,其中CD4+CD25+Foxp3+T细胞是最重要的一群...
Control groups received cells from untreated donors, or buffer alone.After transfer of CD4+CD62L+ T cells from gp96-pretreated donors, mice (TBT gp96) showed an initial weight loss, but after 3 weeks, they recovered and reached the starting weight after 5 weeks. Mice treated with gp96 ...
Why Isolate CD4+/CD62L+/CD44lowNaïve T cells? Mouse CD4+T cells develop in the thymus and are released as naïve T cells that also express CD62L and low levels of CD44. These cells differentiate into subsets of specialized effector T lymphocytes in response to distinct environmental ...
Here, using magnetic beads and fluorescence-activated cell sorting, we extensively phenotype the Tck effector cells and conclude that effector function resides within the CD4+CD45RO+, CCR7-, CD49dhigh population, and that these cells are derived from the effector memory CD4+ T cells in resting...
流式结果也发现,肿瘤引流淋巴结富集效应记忆性T细胞(effector memory T cells,TEM) (CD44+CD62L−), 中央记忆性T细胞(central memory T cells, TCM) (CD44+CD62L+)和TSCM 细胞(CD44−CD62L+)。相比于IL-7/IL-15处理组,IL-2处理的TSCM在肿瘤引流淋巴结中几乎不存在。而在肿瘤中,CLTCH129>Q特异性...
一般来说,记忆性CD4+ T细胞在二级淋巴组织中分为CD62L+CCR7+ 中央记忆T细胞和CD62L-CCR7-效应记忆细胞亚群;其中后者进一步分为Th1,Th2或Th17记忆细胞,具有快速分泌效应细胞因子的潜力,促进对再感染的记忆反应。此外,越来越多的证据支持记忆TFH细胞作为一个独特的记忆细胞亚群。在LCMV感染后,TFH细胞可以持续大于400天...
Objective CD44HighCD62L- is the marker for effector memory T cell. It is well-known that CD4+ T memory cells (Tms) play important role in asthma, but the role of CD8+ T memory cells (Tms) in asthma remains unknown. Here, we analyzed the variation of CD4-Tms in asthmatic mice so ...
SUMMARY Humanmemory (CD45RO+) CD4+Tcells can bedistinguished into twosubpopulations on the basis ofexpression ofthelymphnodehoming receptor, L-selectin (CD62L). Ina prior study we showedthathumanL-selectin-positive memory T-helper (Th)cells promotethematuration of IgG-andIgA-producing cells by...
结论 LFA.1小鼠的CD、CDLnaiveT的诱导分化具有可塑性,在不同刺激因素作用下可 实现iTreg和Tl7细胞之间的诱导转变。 【关键词】 LFA一1～ CD+Foxp3调节性T细胞 TH17细胞分化可塑性 【Abstract】 ObjectiveToexploretheplasticityofiTtreg/T~17cellsinducedinvitrobyCD4+CD62LnaiveTCellsfrom LFA一1 mice.Methods ...