Tim-3 and PD-1 regulate CD8(+) T cell function to maintain early pregnancy in mice. The Journal of reproduction and development. 2017;63(3):289–94. CAS PubMed PubMed Central Google Scholar Wang S, Zhu X, Xu Y, Zhang D, Li Y, Tao Y, Piao H, Li D, Du M: Programmed cell ...
Aging of the CD4 T Cell Compartment Julie S Lefebvre and Laura Haynes* Trudeau Institute, 154 Algonquin ave, Saranac Lake, NY, 12983, USA Abstract Higher morbidity and mortality following infections, particularly influenza, is observed in the elderly population. Because of this, people over 65 ...
on the ontogeny of monoclonal T-cell receptor (TCR)-alphabeta(+)/CD4(+)/NKa(+)/CD8(-/+dim) T-large granular lymphocyte (LGL) lymphocytosis. Becaus... A Rodríguez-Caballero,Andrés C García-Montero,P Bárcena,... - 《Blood》 被引量: 58发表: 2008年 Induction of clinical remission in...
Figure 7. Tr1 sup diminishes DC capability to stimulate both CD4+ and CD8+ T cell responses to Ni. DC were cultured in the presence of sups from either of two Tr1 clones (□, AC2.8; ⋄, AC1.29), a Th0 clone (▵, AC2.11), recombinant IL-10 (○), or left untreated (•)...
Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients. To evaluate the effects of HIV infection on T cell turnover, we examined levels of DNA synthesis in lymph node and peripheral blood mononuclear cell ...
Isoform sequencing (Iso-Seq) uses long-read technology to produce highly accurate full-length reads of mRNA transcripts. Visualization of individual mRNA molecules can reveal new details of transcript variation within understudied portions of mRNA, such as the 5′ untranslated region (UTR). ...
REVIEWS Expanding roles for CD4+ T cells in immunity to viruses Susan L. Swain, K. Kai McKinstry and Tara M. Strutt Abstract | Viral pathogens often induce strong effector CD4+ T cell responses that are best known for their ability to help B cell and CD8+ T cell ...
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种自身免疫性疾病,其致病机制目前尚未完全阐明,可能涉及复制的细胞因子网络[1].在发病过程中,T细胞和B细胞均发生功能异常.为探讨SLE患者T淋巴细胞与中医辨证分型的关系,我们对58例不同证型SLE患者外周血中的CD4+,CD8+两大T淋巴细胞亚群进行了检测,现报道如下....
Bagot M, Echchakir H, Mami-Chouaib F, Delfau-Larue MH, Charue D, Bernheim A, Chouaib S, Boumsell L, Bensussan A (1998) Isolation of tumor-specific cytotoxic CD4+ and CD4+ CD8dim+ T-cell clones infiltrating a cutaneous T-cell lymphoma. Blood 91(11):4331–4341 PubMed CAS Google Sc...
Granzyme B (GrzB) is a serine proteinase expressed by memory T cells and NK cells. Methods to measure GrzB protein usually involve intracellular (flow cytometry) and extracellular (ELISA and ELISpot) assays. CD8 T cells are the main source of GrzB during