肿瘤浸润性CD8 T细胞的转录组预计会与来自同一环境的CD4 Foxp3 Treg细胞和Foxp3-常规CD4 T(Tcon)细胞分开聚集(图1d);观察到CD8 Tex细胞与其祖细胞对应物相比有明显的基因集富集(图1e)。这些数据表明,CD4 Treg细胞和CD8 Tex细胞在TME中的转录程序有一些重叠,这可能支持耗尽的CD8 T细胞在终末分化时拥有抑制性表型。
比如说,就拿大家比较熟知的PD-1,LAG3和TIM3三阳性CD8+ T细胞来说,毫无疑问,过去十几年大家都会认为它是一种衰竭性T细胞。但是这两年最新的研究则是从多个方面证实了这群三阳性CD8 T细胞却具有很强的抗肿瘤功能,而且还和免疫治疗的良好预后密切相关。再比如以往认为肿瘤浸润更多比例的CD8+T...
The ATP-adenosine pathway has emerged as a promising target for cancer therapy, but challenges remain in achieving effective tumor control. Early research focused on blocking the adenosine generating enzyme CD73 and the adenosine receptors A2AR or A2BR i
纯化CD39 PD-1 CD8 T细胞的过继性转移防止了转移性生长。人乳腺癌中,CD39 PD-1 CD8 ,但不是全部的CD8 T细胞的频率与手术切除后的延迟转移性复发(无病生存)相关,因此强调了CD39 PD-1 CD8 T细胞在控制实验和人乳腺癌方面的生物学相关性。因此,本研究认为,原发性乳腺肿瘤可引发系统性CD39 PD-1 CD8 T细胞...
P. et al. CD39 expression defines cell exhaustion in tumor-infiltrating CD8+ T cells. Cancer Res. 78, 115–128 (2018). CAS PubMed Google Scholar Duhen, T. et al. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. Nat. Commun. 9, 2724 ...
L. et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat. Immunol. 14, 1173–1182 (2013). Article CAS Google Scholar McKeown, S. R. Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response. Br. J. ...
We previously reported that CD8+CD103+ T regulatory cells induced exvivo with TGF-β and IL-2(iTregs) inhibited T cells and B cells responses to ameliorate excessive 会议名称: 第十七届国际免疫学大会 会议地点: 中国北京 收藏 引用 批量引用 报错 分享 全部来源 求助全文 kns.cnki.net ...
Furthermore, CD39 enzymatic activity controlled GC-infiltrating CD39hiCD8+ T cell effector function, and blockade of CD39 efficiently enhanced their production of cytokines IFN-γ and TNF-α. Finally, high percentages of GC-infiltrating CD39hiCD8+ T cells correlated with tumor progression and ...
cd47-sirpα轴的抑制剂(例如,抗体或结合至cd47或sirpα并抑制所述两种分子的相互作用的其他结合部分)、cd24-siglec-10轴的抑制剂(例如,抗体或结合至cd24或siglec-10并抑制所述两种分子的相互作用的其他结合部分)、阻断nk和cd8+细胞的hla-e驱动的抑制的ngk2a检查点抑制剂、sting激动剂、tlr7/8激动剂和rig-i激动...
CD8 þ T cells are one of the major adaptive immune cells. Type 1 CD8 þ T cells (Tc1) have been reported to release high levels of IFNg (ref. 10), and have been implicated in pathogen clearance, immune diseases and in antitumor immunity11,12. Recent data have shown that together...