细胞与分子免疫学:英文版Chen X, Liu Q, Xiang AP. CD8+CD28- T cells: not only age- related cells but a subset of regulatory T cells. Cell Mol Immunol 2018; 15(8): 734-36.
TCR，Ca2+和CD28一起形成正向反馈，显著放大T细胞信号传导，从而提高T细胞对抗原的敏感性。TCR和CD28信号的传导主要通过CD28的细胞质内41个氨基酸胞质区来发挥作用。胞质区包含富含酪氨酸为基础的活性结合域，这些结合域可以和蛋白激酶或者结合蛋白反应影响T细胞的活动。例如，在这个过程中会调节IL-2基因的表达。因此，CD...
[13] CHEN C, CHEN D, ZHANG Y, et al. Changes of CD4+CD25+FOXP3+ and CD8+CD28- regulatory T cells in non-small cell lung cancer patients undergoing surgery [J]. Int Immunopharmacol, 2014, 18(2): 255-61. [14] CASADO J G, SOTO R, DELAROSA O...
且CD8+T细胞的IFN-γ、颗粒酶B和穿孔素等关键功能分子表达明显上调,说明被激活进入了战斗力超强的状态,而在体内实验(使用多西环素诱导敲低Cd28)中的发现也基本相同,即敲低TNBC细胞的Cd28不仅可以有效抑癌,还能克服TNBC细胞对PD-1抑制剂治疗的耐药。
One population of interest is the CD28 CD8+ T cell subset, which are late-differentiated cells also described as suppressors. These cells are altered in a number of disease states and have been shown to be reduced in adults with T1D. We found that the proportion of CD28 cells within the ...
近日,来自美国宾夕法尼亚大学的Jaikumar Duraiswamy和瑞士洛桑大学的George Coukos研究组合作在Cancer Cell杂志上发表题为Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation的文章,发现在人类卵巢癌中,TIL的功能维持需要抗原递呈细胞上的CD28共刺激。
Gene expression and generation of CD28-CD8 T cells mediated by interleukin 15. Accumulation of CD28CD8 T cells that are defective in response to antigenic stimulation is a hallmark of age-associated decline in T cell function. However... J Godlove,WK Chiu,NP Weng - 《Experimental Gerontology...
期肾癌患者的Ⅰ类推荐,因此对于晚期难治性肾癌首选阿昔替尼治疗.树突状细胞(dendritic cell,DC)对肿瘤细胞抑制有重要作用,aRCC 患者血液中 DC 和 CD28+,CD8+,... 许振胜,符芳姿,王美清,李建旺,张玮芳 - 《国际肿瘤学杂志》 被引量: 0发表: 2016年 ...
研究表明,在原代人CD3+T细胞重组的免疫缺陷NSG小鼠体内该三抗使CD8 T细胞中颗粒酶的表达增加了6.8倍。在剂量低至10μg kg−1时,该三抗完全抑制了HER2-high HCC1954 乳腺癌细胞(453,780 molecules per cel)。研究还测试了该三抗在HER2-lowZR-75-1细胞系(52,045 molecules percell)中的疗效,结果显示,剂量低...
系统性红斑狼疮CD8(上标 +) T细胞CD28表达与中医分型的关系 Objective: To explore the relationship between CD8(superscript +) T-Cell CD28 molecular expression in peripheral blood and Traditional Chinese medicine (TCM) Differentiation Type in patients with systemic lupus erythematosus (SLE). Metho... 朱...