在接受NAT的BC患者中,活化的CD24hiCD27+Bregs与mLN内残留的肿瘤细胞之间存在密切的空间相关性。 机制上,CD24hiCD27+ Bregs通过分泌IL-6和TNF-a显著增强了BC细胞多药耐药性和类干细胞特征。更重要的是,BC细胞通过CD40L-和PD-L1依赖的近端信号进一步促进了CD24hiCD27+Bregs的激活,形成了一个正反馈模式。PD...
More importantly, breast cancer cells further promote the activation of CD24hiCD27+ Bregs via CD40L-dependent and PD-L1鈥揹ependent proximal signals, forming a positive feedback pattern. PD-L1 blockade significantly attenuates the drug resistance of breast cancer cells induced by CD24hiCD27+ B...
结果表明,在肝移植术后出现急性排斥反应的患者中,外周血中CD19+CD24hiCD27+ mBreg细胞的数量和免疫抑制功能均受到损害。在体外实验中,miR-29a-3p被发现是mBregs分化的调节因子。靶向活化T细胞核因子5(NFAT5)的miR-29a-3p被抑制...
Interestingly, primary CD24(hi) CD27(+) CD19(+) B cells inversely correlated with SLE disease activity index (SLEDAI) score. Patients with arthritis and hematologic disorders had a lower primary CD24(hi) CD27(+) CD19(+) B cells. In...
Differentiation and immunosuppressive function of CD19+CD24hiCD27+ regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway Jin-Yang Li a , b , c , # , Tian-Shuo Feng a , b , c , # , Ji Gao a , b , c , Xin-Xiang Yang a , b , c , Xiang-Cheng Li a , ...
In this study, we found that CD19 +CD24 hiCD27 + Bregs and IL-10 +CD19 + Bregs were significantly increased in the peripheral blood samples of BP patients compared with that in healthy controls. Moreover, compared to Bregs from healthy individuals, we found that Bregs from BP ...
as well as investigated the immune functions of patient-derived Bregsin vitro. Unexpectedly, we found that the frequency of circulating CD19+CD24hiCD27+Bregs was elevated in BP patients, compared with that in healthy controls. In addition, these Bregs displayed immunodeficiency in suppressing auto...
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24临床(5+3)1班 姓名:张洪瑄 班级:22临床(5+3)1班 个人介绍: ①任职情况:任文体委员,曾任Chocolate滑板协会副会长,预备党员。 ②技能成就:长板、室内&户外冲浪、篮球、手球、飞盘、自由泳、一丢丢民谣吉他。 ③自我认知:温医命运共同体,...