CCL3 is important in orchestrating cellular contacts in vaccinated lymph nodes (LNs) and enhancing memory T cell generation. Furthermore, dendritic cells (DCs) have been shown to mediate both tumor-tolerance and antitumor immunity in some tumor models. We hypothesize that incorporating CCL3 into ...
MIP-1 alpha (macrophage inflammatory protein 1 alpha) is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T ...
Inappropriate chemokine/receptor expression or regulation has been linked with several diseases, especially those characterized by an excessive cellular infiltrate [44]. There is now overwhelming evidence that chemokines are also involved in the progression of cancer [45]. Overexpression of CCL3 has been...
or i.d. immunization. Representative histograms after i.m. DNA immunization are dispayed on the left. Percentage of CTVlow and CTVhigh cells are indicated within each histogram. The cytotoxicity data is summarized in the right graph. (C) Cytotoxicity assay as in (B) performed in BATF3 ...
Clear-cell renal cell carcinoma is one of the most common tumors disagnosed, with nearly one third of patients diagnosed with metastatic ccRCC. Although an increasing number of studies has revealed that piwi-interacting RNAs are aberrantly expressed in diverse types of cancers, few of them explor...
CCL4 is largely specific for CCR5, whereas CCL3 and CCL5 also bind to other chemokine receptors (CCR1 and CCR3). It was subsequently found that CCR5 binds a large number of endogenous chemokine ligands and that CCL3-L1 (a CCL3 variant, originally called LD78β or MIP-1αP) is the ...
homing of different lymphocyte subsets to the CNS is likely an important factor in defining the composition of the inflammatory infiltrates at different stages of the MS lesions and other inflammatory CNS diseases. Article Access Statistics here ...
www.nature.com/scientificreports OPEN CCL3L3‑null status is associated with susceptibility to systemic lupus erythematosus Young‑Ho Kim1,6, Eunyoung Emily Lee2,6, Hye‑Won Sim1, Eun‑Kyung Kang1, Yoon‑Ho Won1, Dong‑eun Lee3, Kyeong‑Man Hong1* &...
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