In the heart, ion channels generate electrical currents that signal muscle contraction through changes in intracellular calcium concentration, i.e., [Ca2+]. The cardiac ryanodine receptor type 2 (RyR2) is the predominant ion channel responsible for increasing intracellular [Ca2+] by releasing Ca2+ ...
Cardiac muscle, in vertebrates, one of three major muscle types, found only in the heart. Cardiac muscle possesses contractile units known as sarcomeres and exhibits rhythmic contractions. The rhythmic contractions are regulated by the sinoatrial node of
Cardiac Muscle: Contraction Process, Ion Channels & Cardiomyocytes 5:47 Next Lesson Conduction System of the Heart | Anatomy, Nodes & Pathway Blood Flow Through the Heart | Diagram, Order & Role5:51 Coronary Circulation of the Heart Cardiac Output: Circulation, Heart Rate & Physiological Factors...
Cardiac muscle function is governed by the intracellular control of sarcomere contraction and force generation. Based on the biochemistry of crossbridge cycling and calcium kinetics, two main feedback mechanisms are postulated to affect the dynamics of contractile filaments. These two feedback loops ...
The meaning of CARDIAC MUSCLE is the principal involuntary-muscle tissue of the vertebrate heart made up of striated fibers joined at usually branched ends and functioning in synchronized rhythmic contraction.
their unique mechanism of action involves directly activating the enzymatic pathway in the cardiac myocyte as a way to improve ventricular contraction. Preclinical and clinical trials have found that omecamtiv mecarbil improves cardiac contractility without increasing the risk of any of the harmful effe...
S. TRPA1 is functionally co-expressed with TRPV1 in cardiac muscle: co-localization at Z-discs, costameres and intercalated discs. Channels 10, 395–409 (2016). Article PubMed PubMed Central Google Scholar Bodkin, J. V. et al. Investigating the potential role of TRPA1 in locomotion ...
Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc. Natl Acad. Sci. USA 90, 347–351 (1993). CAS PubMed Google Scholar Han, X. et al. Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of ...
BackgroundTroponin T type 2 (cardiac), also known as TNNT2, is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations of this...
Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important. It is crucial to the very process that enables the chambers of the heart to contract and relax, a process called excitation–contraction coupling. It is important to understand in quan...