CELLGLYCOLYSISTUMORPROMOTESEXPRESSIONGastric cancer is the fifth most common malignancy worldwide having the fourth highest mortality rate. Energy metabolism is key and closely linked to tumour development. Most important in the reprogramming of cancer metabolism is the Warburg effe...
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Our goal is to revisit the argument of tumor cell origin and to provide a general hypothesis that genomic mutability and essentially all hallmarks of cancer, including the Warburg effect, can be linked to impaired respiration and energy metabolism. In brief, damage to cellular respiration precedes ...
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can be linked to activation of oncogenes or loss of tumor
Clear cell renal cell carcinoma (ccRCC) is known for abnormal lipid metabolism and widespread activation of HIF-2α. Recently, the importance of autophagy in ccRCC has been focused, and it has potential connect... Authors: Yu Huang, Zhiyong Xiong, Jianjun Wang, Yafen Gao, Qi Cao, Decai ...
As chromanols are active components of naturally occurring antioxidants (e.g., Vitamin-E and tocotrienols), we surmised that it is critically important to understand the changes in breast cancer cell energy metabolism induced by mitochondria targeted chromanols (Additional file 1: Figure S1). Here...
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Suppression of cellular metabolism to provide just the minimal energy required to maintain cytostasis. Ionophores Molecules that facilitate the movement of ions across the cell membrane, normally by the formation of pores. Nernst equilibrium potential A mathematical formula that describes the equilibrium ...
adopted by the cancer cell could be the preferred target of anti-neoplastic strategies. Otherwise, therapeutic strategies simultaneously targeting several routes of lipid provision might be required. Lipid metabolism under hypoxic conditions FA synthesis under hypoxic conditions...