Activation of the engineered G-protein coupled receptor with the synthetic compound clozapine-N-oxide (CNO) evoked a short and transient Ca2+ peak in podocytes immediately after CNO administration in vivo. Interestingly, this Ca2+ peak did neither affect glomerular perfusion nor filtration in the ...
there are three isoforms. RyR1 and RyR2 are involved in skeletal and cardiac muscle excitation–contraction coupling, respectively2, and are also found in non-muscle tissues3, while RyR3, originally identified in the brain4, is expressed in many tissues...